Genetics of Steroid Receptors and Their Disorders

  • Leonard Pinsky
  • Morris Kaufman
Part of the Advances in Human Genetics book series (AHUG, volume 16)

Abstract

It is axiomatic that the extraordinary diversity in form and function of cells, tissues, and organs within a higher organism results not from differences in their genomic composition, but from the finely tuned selective expression of portions of their common genetic repertoires. The fact that steroids act as gene-regulating molecules, and that they do so, for the most part, by acting as allosteric modifiers of their respective receptor (R) proteins, has focused much attention on the manner in which steroid—receptor (S—R) complexes act to regulate gene expression, particularly at the level of gene transcription.

Keywords

Androgen Receptor Luteinizing Hormone Glucocorticoid Receptor Steroid Receptor Androgen Receptor Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Leonard Pinsky
    • 1
  • Morris Kaufman
    • 1
  1. 1.The Lady Davis Institute for Medical Research Sir Mortimer B. Davis-Jewish General Hospital and Centre for Human Genetics Departments of Pediatrics and BiologyMcGill UniversityMontrealCanada

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