Cerebral Amino Acid Pools

  • Thomas L. Perry

Abstract

This chapter is intended to present a survey of the free amino acids and related compounds that can be identified and quantitated in human brain and in the brains of commonly used species of laboratory mammals. Even though the word “free” may often be omitted, I refer only to those compounds that are detectable without hydrolysis of brain extracts. N-Acetylated amino acids, for instance, are not considered. For convenience, I have included with the amino acids several amines such as glycerophosphoethanolamine, phosphoethanolamine, and ethanolamine and several small peptides such as GSH, GSSG, and homocarnosine, since these amino compounds are readily measured together with true amino acids by many amino acid analyzer techniques.

Keywords

Cerebellar Cortex Glutamic Acid Decarboxylase Dentate Nucleus Amino Compound Maple Syrup Urine Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kuriyama, K., Roberts, E., and Rubinstein, M. K., 1966, Biochem. Pharmacol. 15: 221–236.PubMedCrossRefGoogle Scholar
  2. 2.
    Balcom, G. J., Lenox, R. H., and Meyerhoff, J. L., 1975, J. Neurochem. 24: 609–613.PubMedGoogle Scholar
  3. 3.
    van der Heyden, J. A. M., and Korf, J., 1978, J. Neurochem. 31: 197–203.PubMedCrossRefGoogle Scholar
  4. 4.
    Tallan, H. H., Moore, S., and Stein, W. H., 1956, J. Biol. Chem. 219: 257–264.Google Scholar
  5. 5.
    Tews, J. K., Carter, S. H. Roa, P. D., and Stone, W. E., 1963, J. Neurochem. 10: 641–653.PubMedCrossRefGoogle Scholar
  6. 6.
    Duggan, A. W., and Johnston, G. A. R., 1970, J. Neurochem. 17: 1205–1208.PubMedCrossRefGoogle Scholar
  7. 7.
    Tachiki, K. H., and Baxter, C. F., 1979, J. Neurochem. 33: 1125–1129.PubMedCrossRefGoogle Scholar
  8. 8.
    Shank, R. P., and Aprison, M. H., 1970, Anal. Biochem. 35: 136–145.PubMedCrossRefGoogle Scholar
  9. 9.
    Aprison, M. H., McBride, W. J., and Freeman, A. R., 1973, J. Neurochem. 21: 87–95.PubMedCrossRefGoogle Scholar
  10. 10.
    Smith, J. E., Lane, J. D., Shea, P. A., McBride, W. J., and Aprison, M. H., 1975, Anal. Biochem. 64: 149–169.PubMedCrossRefGoogle Scholar
  11. 11.
    Sturman, J. A., and Gaull, G. E., 1975, J. Neurochem. 25: 831–835.PubMedCrossRefGoogle Scholar
  12. 12.
    Sturman, J. A., Rassin, D. K., Gaull, G. E., and Cote, L. J., 1980, J. Neurochem. 35: 304–310.PubMedCrossRefGoogle Scholar
  13. 13.
    Perry, T. L., Berry, K., Hansen, S., Diamond, S., and Mok, C., 1971, J. Neurochem. 18: 513–519.PubMedCrossRefGoogle Scholar
  14. 14.
    Perry, T. L., Hansen, S., Berry, K., Mok. C., and Lesk, D., 1971, J. Neurochem. 18: 521–528.PubMedCrossRefGoogle Scholar
  15. 15.
    Starr, M. S., 1975, J. Neurochem. 24: 1229–1236.PubMedCrossRefGoogle Scholar
  16. 16.
    Joseph, M. H., and Halliday, J. A., 1975, Anal. Biochem. 64: 389–402.PubMedCrossRefGoogle Scholar
  17. 17.
    Emson, P. C., 1976, J. Neurochem. 27: 1489–1494.PubMedCrossRefGoogle Scholar
  18. 18.
    Hirsch, H. E., and Robins, E.. 1962, J. Neurochem. 9: 63–70.PubMedCrossRefGoogle Scholar
  19. 19.
    Baxter, C. F., and Roberts, E., 1959, Proc. Soc. Exp. Biol. Med. 101: 811–815.Google Scholar
  20. 20.
    Kravitz, E. A., and Potter, D. D., 1965, J. Neurochem. 12: 323–328.PubMedCrossRefGoogle Scholar
  21. 21.
    Graham, L. T., Jr., and Aprison, M. H., 1966, Anal. Biochem. 15: 487–497.PubMedCrossRefGoogle Scholar
  22. 22.
    Enna, S. J., and Snyder, S. H., 1976, J. Neurochem. 26: 221–224.PubMedCrossRefGoogle Scholar
  23. 23.
    Lloyd, K. G., and Hornykiewicz, O., 1977, Life Sci. 21: 1489–1496.PubMedCrossRefGoogle Scholar
  24. 24.
    Ferkany, J. W., Butler, I. J., and Enna, S. J., 1979, J. Neurochem. 33: 29–33.PubMedCrossRefGoogle Scholar
  25. 25.
    Levi, G., Amaldi, P., and Morisi, G., 1972, Brain Res. 41: 435–451.PubMedCrossRefGoogle Scholar
  26. 26.
    Jung, M. J., Lippert, B., Metcalf, B. W., Schechter, P. J., Böhlen, P., and Sjoerdsma, A., 1977, J. Neurochem. 28: 717–723.PubMedCrossRefGoogle Scholar
  27. 27.
    Schechter, P. J., Tranier, Y., Jung, M. J., and Böhlen, P., 1977, Eur. J. Pharmacol. 45: 319–328.PubMedCrossRefGoogle Scholar
  28. 28.
    Perry, T. L., Stedman, D., and Hansen, S., 1968, J. Chromatogr. 38: 460–466.PubMedCrossRefGoogle Scholar
  29. 29.
    Benson, J. V., Jr., Gordon, M. J., and Patterson, J. A., 1967, Anal. Biochem. 18: 228–240.CrossRefGoogle Scholar
  30. 30.
    Benson, J. V., Jr., 1972, Anal. Biochem. 50: 477–493.PubMedCrossRefGoogle Scholar
  31. 31.
    Benson, J. R., and Hare, P. E., 1975, Proc. Natl. Acad. Sci. U.S.A. 72: 619–622.Google Scholar
  32. 32.
    Agrawal, H. C., Davis, J. M., and Himwich, W. A., 1966–1967, Brain Res. 3: 374–380.Google Scholar
  33. 33.
    Jung, M. J., Lippert, B., Metcalf, B. W., Böhlen, P., and Schechter, P. J., 1977, J. Neurochem. 29: 797–802.PubMedCrossRefGoogle Scholar
  34. 34.
    Minard, F. N., and Mushahwar, 1. K., 1966, Life Sci. 5: 1409–1413.PubMedCrossRefGoogle Scholar
  35. 35.
    Shank, R. P., and Aprison, M. H., 1971, J. Neurobiol. 2: 145–151.PubMedCrossRefGoogle Scholar
  36. 36.
    Lajtha, A., and Toth, J., 1974, Brain Res. 76: 546–551.PubMedCrossRefGoogle Scholar
  37. 37.
    Perry, T. L., Hansen, S., and Gandham, S. S., 1981, J. Neurochem. 36: 406–412.PubMedCrossRefGoogle Scholar
  38. 38.
    Spokes, E. G. S., and Koch, D. J., 1978, J. Neurochem. 31: 381–383.PubMedCrossRefGoogle Scholar
  39. 39.
    Perry, T. L., Kish, S. J., and Hansen, S., 1979, J. Neurochem. 32: 1641–1645.PubMedCrossRefGoogle Scholar
  40. 40.
    Perry, T. L., Sanders, H. D., Hansen, S., Lesk, D., Kloster, M., and Gravlin, L., 1972, J. Neurochem. 19: 2651–2656.PubMedCrossRefGoogle Scholar
  41. 41.
    Hansen, S., Perry, T. L., Wada, J. A., and Sokol, M., 1973, Brain Res. 50: 480–483.PubMedCrossRefGoogle Scholar
  42. 42.
    Himwich, W. A., and Agrawal, H. C., 1969, Handbook of Neurochemistry, Volume 1: Chemical Architecture of the Nervous System, 1st ed. (A. Lajtha, ed.), Plenum Press, New York, pp. 33–52.Google Scholar
  43. 43.
    Peck, E. J., Jr., and Awapara, J., 1967, Biochim. Biophys. Acta 141: 499–506.Google Scholar
  44. 44.
    Perry, T. L., and Hansen, S., 1973, J. Neurochem. 21: 1009–1011.PubMedCrossRefGoogle Scholar
  45. 45.
    Kakimoto, Y., Nakajima, T., Kumon, A., Matsuoka, Y., Imaoka, N., Sano, I., and Kanazawa, A., 1969, J. Biol. Chem. 244: 6003–6007.Google Scholar
  46. 46.
    Sturman, J. A., Rassin, D. K., and Gaull, G. E., 1977, J. Neurochem. 28: 31–39.PubMedCrossRefGoogle Scholar
  47. 47.
    Hayes, K. C.; Carey, R. E., and Schmidt, S. Y., 1975, Science 188: 949–951.PubMedCrossRefGoogle Scholar
  48. 48.
    Schmidt, S. Y., Berson, E. L., and Hayes, K. C., 1976, Invest. Ophthalmol. 15: 52–58.PubMedGoogle Scholar
  49. 49.
    Sturman, J. A., Rassin, D. K., and Gaull, G. E., 1978, Taurine and Neurological Disorders (A. Barbeau and R. J. Huxtable, eds.), Raven Press, New York, pp. 49–71.Google Scholar
  50. 50.
    Margolis, F. L., 1974, Science 184: 909–911.PubMedCrossRefGoogle Scholar
  51. 51.
    Neidle, A., and Kandera, J., 1974, Brain Res. 80: 359–364.PubMedCrossRefGoogle Scholar
  52. 52.
    Harding, J., and Margolis, F. L., 1976, Brain Res. 110: 351–360.PubMedCrossRefGoogle Scholar
  53. 53.
    Perry, T. L., and Hansen, S., 1981, Neurology (Minneap.) 31: 872–876.CrossRefGoogle Scholar
  54. 54.
    Perry, T. L., Hansen, S., and Kloster, M., 1972, J. Neurochem. 19: 1395–1396.PubMedCrossRefGoogle Scholar
  55. 55.
    Perry, T. L., Hansen, S., Schier, G. M., and Halpern, B., 1977, J. Neurochem. 29: 791–795.PubMedCrossRefGoogle Scholar
  56. 56.
    Kish, S. J., Perry, T. L., and Hansen, S., 1979, J. Neurochem. 32: 1629–1636.PubMedCrossRefGoogle Scholar
  57. 57.
    Kanazawa, I., Miyata, Y., Toyokura, Y., and Otsuka, M., 1973, Brain Res. 51: 363–365.PubMedCrossRefGoogle Scholar
  58. 58.
    Kanazawa, I., and Toyokura, Y., 1975, Brain Res. 100: 371–381.PubMedCrossRefGoogle Scholar
  59. 59.
    Rossor, M., Garrett, N., and Iversen, L., 1980, J. Neurochem. 35: 743–745.PubMedCrossRefGoogle Scholar
  60. 60.
    Lombardini, J. B., 1978, Taurine and Neurological Disorders (A. Barbeau and R. J. Huxtable, eds.), Raven Press, New York, pp. 119–135.Google Scholar
  61. 61.
    Perry, T. L., MacLean, J., Perry, T. L., Jr., and Hansen, S., 1976, Brain Res. 109: 632–635.PubMedCrossRefGoogle Scholar
  62. 62.
    Perry, T. L., Hansen, S., and Kish, S. J.. 1979, Life Sci. 24: 283–288.PubMedCrossRefGoogle Scholar
  63. 63.
    McBride, W. J., Nadi, N. S., Altman, J., and Aprison, M. H., 1976, Neurochem. Res. 1: 141–152.CrossRefGoogle Scholar
  64. 64.
    Nadi, N. S., McBride, W. J., and Aprison, M. H., 1977, J. Neurochem. 28: 453–455.PubMedCrossRefGoogle Scholar
  65. 65.
    McBride, W. J., Rea, M. A., Fetten, D. L., and Rohde, B. H., 1980, Neurochem. Res. 5: 337–344.PubMedCrossRefGoogle Scholar
  66. 66.
    Rizzoli, A. A., 1968, Brain Res. 11: 11–18.PubMedCrossRefGoogle Scholar
  67. 67.
    Agrawal, H. C., Davis, J. M., and Himwich, W. A., 1968, J. Neurochem. 15: 917–923.PubMedCrossRefGoogle Scholar
  68. 68.
    Agrawal, H. C., Davis, J. M., and Himwich, W. A., 1968, J. Neurochem. 15: 529–531.PubMedCrossRefGoogle Scholar
  69. 69.
    Sturman, J. A., Rassin, D. K., and Gaull, G. E., 1977, Life Sci. 21: 1–22.PubMedCrossRefGoogle Scholar
  70. 70.
    Kremzner, L. T., and Sturman, J. A., 1979, J. Neurochem. 33: 1115–1117.PubMedCrossRefGoogle Scholar
  71. 71.
    McGeer, E. G., and McGeer, P. L., 1979, GABA-Neurotransmitters: Pharmacochemical, Biochemical and Pharmacological Aspects (P. Krogsgaard-Larsen, J. Scheel-Krüger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 340–356.Google Scholar
  72. 72.
    Perry, T. L., Kish, S. J., Hansen, S., Wright, J. M., Wall, R. A., Dunn, W. L., and Bellward, G. D., 1981, J. Neurochem. 37: 32–39.PubMedCrossRefGoogle Scholar
  73. 73.
    Schatz, R. A., and Lal, H., 1971, J. Neurochem. 18: 2553–2555.PubMedCrossRefGoogle Scholar
  74. 74.
    Popov, N., and Matthies, H., 1969, J. Neurochem. 16: 899–907.PubMedCrossRefGoogle Scholar
  75. 75.
    Perry, T. L., and Hansen, S., 1973, J. Neurochem. 21: 1167–1175.PubMedCrossRefGoogle Scholar
  76. 76.
    Wood, J. D., Peesker, S. J., Gorecki, D. K. J., and Tsui, D., 1978, Can. J. Physiol. Pharmacol. 56: 62–68.Google Scholar
  77. 77.
    Fowler, L. J., 1973, J. Neurochem. 21: 437–440.PubMedCrossRefGoogle Scholar
  78. 78.
    Fletcher, A., and Fowler, L. J., 1980, Biochem. Pharmacol. 29: 1451–1454.PubMedCrossRefGoogle Scholar
  79. 79.
    Perry, T. L., Urquhart, N., Hansen, S., and Kennedy, J., 1974, J. Neurochem. 23: 443–445.PubMedCrossRefGoogle Scholar
  80. 80.
    Perry, T. L., and Hansen, S., 1978, J. Neurochem. 30: 679–684.PubMedCrossRefGoogle Scholar
  81. 81.
    Schechter, P. J., Tranier, Y., Jung, M. J., and Sjoerdsma, A., 1977, J. Pharmacol. Exp. Ther. 201: 606–612.Google Scholar
  82. 82.
    Schechter, P. J., Tranier, Y., and Grove, J., 1979, Life Sci. 24: 1173–1182.PubMedCrossRefGoogle Scholar
  83. 83.
    Godin, Y., Heiner, L., Mark, J., and Mandel, P., 1969, J. Neurochem. 16: 869–873.PubMedCrossRefGoogle Scholar
  84. 84.
    Simler, S., Ciesielski, L., Maitre, M., Randrianarisoa, H., and Mandel, P., 1973, Biochem. Pharmacol. 22: 1701–1708.PubMedCrossRefGoogle Scholar
  85. 85.
    Harvey, P. K. P., Bradford, H. F., and Davison, A. N., 1975, FEBS Lett. 52: 251–254.PubMedCrossRefGoogle Scholar
  86. 86.
    Kuriyama, K., and Yoneda, Y., 1978, Brain Res. 148: 163–179.PubMedCrossRefGoogle Scholar
  87. 87.
    Horton, R. W., 1978, Biochem. Pharmacol. 27: 1471–1477.PubMedCrossRefGoogle Scholar
  88. 88.
    Horton, R. W., Chapman, A. G., and Meldrum, B. S., 1978, J. Neurochem. 30: 1501–1504.PubMedCrossRefGoogle Scholar
  89. 89.
    Reingold, D. F., and Orlowski, M., 1979, J. Neurochem. 32: 907–913.PubMedCrossRefGoogle Scholar
  90. 90.
    Pajunen, A. E. I., Hietala, O. A., Baruch-Virransalo, E.-L., and Piha, R. S., 1979, J. Neurochem. 32: 1401–1408.PubMedCrossRefGoogle Scholar
  91. 91.
    Perry, T. L., Hansen, S., and MacLean, J., 1976, Clin. Chim. Acta 69: 441–445.Google Scholar
  92. 92.
    Coutter, D. L., and Allen, R. J., 1980, Lancet 1: 1310–1311.CrossRefGoogle Scholar
  93. 93.
    McKean, C. M., and Peterson, N. A., 1970, N. Engl. J. Med. 283: 1364–1367.Google Scholar
  94. 94.
    Prensky, A. L., and Moser, H. W., 1966, J. Neurochem. 13: 863–874.PubMedCrossRefGoogle Scholar
  95. 95.
    Gerritsen, T., and Waisman, H. A., 1964, Science 145: 588.PubMedCrossRefGoogle Scholar
  96. 96.
    Brenton, D. P., Cusworth, D. C., and Gaull, G. E., 1965, Pediatrics 35: 50–56.PubMedGoogle Scholar
  97. 97.
    Perry, T. L., Hardwick, D. F., Dixon, G. H., Dolman, C. L., and Hansen, S., 1965, Pediatrics 36: 236–250.PubMedGoogle Scholar
  98. 98.
    Scriver, C. R., Pueschel, S., and Davies, E., 1966, N. Engl. J. Med. 274: 636–643.Google Scholar
  99. 99.
    Gerritsen, T., and Waisman, H. A., 1978, The Metabolic Basis of Inherited Disease, 4th ed. (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), McGraw-Hill. New York, pp. 514–517.Google Scholar
  100. 100.
    Shih, V. E., 1978, The Metabolic Basis of Inherited Disease, 4th ed. (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), McGraw-Hill, New York, pp. 362–386.Google Scholar
  101. 101.
    Perry, T. L., Wirtz, M. L. K., Kennaway, N. G., Hsia, Y. E., Atienza, F. C., and Uemura, H. S., 1980, Clin. Chim. Acta 105: 257–267.Google Scholar
  102. 102.
    Marstein, S., and Perry, T. L., 1981, Clin. Chim. Acta 109: 13–20.Google Scholar
  103. 103.
    Marstein, S., Jellum, E., Nesbakken, R., and Perry, T. L., 1981, Clin. Chim. Acta 111: 219–228.Google Scholar
  104. 104.
    Gjessing, L. R., and Sjaastad, 0., 1974, Lancet 2: 1028.Google Scholar
  105. 105.
    Perry, T. L., Kish, S. J., Sjaastad, 0., Gjessing, L. R., Nesbakken, R., Schrader, H., and L¢ken, A. C., 1979, J. Neurochem. 32: 1637–1640.PubMedCrossRefGoogle Scholar
  106. 106.
    Perry, T. L., Urquhart, N., MacLean, J., Evans, M. E., Hansen, S., Davidson, A. G. F., Applegarth, D. A., MacLeod, P. J., and Lock, J. E., 1975, N. Engl. J. Med. 292: 1269–1273.Google Scholar
  107. 107.
    Perry, T. L., Urquhart, N., Hansen, S., and Marner, O. A., 1977, Pediatr. Res. 12: 1192–1197.CrossRefGoogle Scholar
  108. 108.
    Perry, T. L., Hansen, S., and Kloster, M., 1973, N. Engl. J. Med. 288: 337–342.Google Scholar
  109. 109.
    Bird, E. D., and Iversen, L. L., 1974, Brain 97: 457–472.PubMedCrossRefGoogle Scholar
  110. 110.
    Urquhart, N., Perry, T. L., Hansen, S., and Kennedy, J., 1975, J. Neurochem. 24: 1071–1075.PubMedCrossRefGoogle Scholar
  111. 111.
    Bird, E. D., MacKay, A. V. P., Rayner, C. N., and Iversen, L. L., 1973, Lancet 1: 1090–1092.PubMedCrossRefGoogle Scholar
  112. 112.
    Gale, J. S., Bird, E. D., Spokes, E. G., Iversen, L. L., and Jessell, T., 1978, J. Neurochem. 30: 633–634.PubMedCrossRefGoogle Scholar
  113. 113.
    Perry, T. L., Kish, S. J., Hansen, S., and Currier, R. D., 1981, Neurology (Minneap.) 31: 237–242.CrossRefGoogle Scholar
  114. 114.
    Perry, T. L., Kish, S. J., Buchanan, J., and Hansen, S., 1979, Lancet 1: 237–239.PubMedCrossRefGoogle Scholar
  115. 115.
    Roberts, E., 1972, Neurosci. Res. Program Bull. 10: 468–481.PubMedGoogle Scholar
  116. 116.
    Perry, T. L., 1978, Taurine and Neurological Disorders (A. Barbeau and R. J. Huxtable, eds.), Raven Press, New York, pp. 441–451.Google Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Thomas L. Perry
    • 1
  1. 1.Department of PharmacologyUniversity of British ColumbiaVancouverCanada

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