Computer-based auditory neurophysiology laboratory

  • J. E. Hind
  • W. S. Rhode
Part of the FASEB Monographs book series (FASEBM, volume 2)

Abstract

For nearly 2 decades our laboratory has carried on microelectrode studies of the auditory nervous system. A primary objective of these studies is to determine how the properties of an acoustical stimulus are represented or coded in the temporal patterns of all-or-none spike discharges that may be recorded from single neural units (cell bodies or fibers). For many years, following the pioneering observations of Galambos and Davis (3), the only available methods for study of unit discharge patterns involved either laborious manual measurement of oscilloscope tracings or rough estimation of the threshold of unit discharge by listening to the amplified activity. Although qualitative techniques were developed to deal with the massive amounts of data that result from experiments of this kind, it was not until Gerstein and Kiang (4) and their colleagues at MIT introduced the digital computer that it became possible to perform precise statistical analyses of unit discharge patterns as they occur in real time.

Keywords

Basilar Membrane Auditory Nerve Fiber Digital Timer Period Histogram Digital Oscillator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brugge, J. F., D. J. Anderson, J. E. Hind and J. E. Rose. Time structure of discharges in single auditory nerve fibers of the squirrel monkey in response to complex periodic sounds. J. Neurophyswl. 32: 386–401, 1969.Google Scholar
  2. 2.
    Clark, W. A., and C. E. Molnar. A description of the LINC. In: Computers in biomedical research, edited by R. W. Stacy and B. Waxman, New York: Academic, 1965.Google Scholar
  3. 3.
    Galambos, R., and H. Davis. The response of single auditory-nerve fibers to acoustic stimulation. J. Neurophysiol. 6: 39–57, 1943.Google Scholar
  4. 4.
    Gerstein, G. L., and N. Y.-S. Kiang. An approach to the quantitative analysis of electrophysiological data from single neurons. Biophys. J. 1: 15–28, 1960.CrossRefGoogle Scholar
  5. 5.
    Hind, J. E., and H. Ludwig. Adaptation of the CDC 160 computer to measurement of the temporal discharge characteristics of single neural units. Proc. 16th Ann. Conf. Eng. Med. Bwl. 5: 64–65, 1963.Google Scholar
  6. 6.
    Rhode, W. S. Observations of the vibration of the basilar membrane in squirrel monkeys using the Mössbauer technique. J. Acoust. Soc. Am. 49: 1218–1231, 1971.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • J. E. Hind
    • 1
  • W. S. Rhode
    • 1
  1. 1.Medical SchoolUniversity of WisconsinMadisonUSA

Personalised recommendations