Biochemistry of Coronaviruses 1980

  • Brian W. J. Mahy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


The coronavirus is something of a wolf in sheep’s clothing. Originally identified as a large pleomorphic enveloped RNA virus with unique external morphological features and a helical internal nucleocapsid (Tyrrell et al., 1975), the close parallels with negative strand RNA viruses prompted many investigators to search for a coronavirion transcriptase. It soon became clear however, that, despite their morphological appearance, the coronaviruses possess an infectious genome RNA which must, by definition, be of positive polarity.


Infectious Bronchitis Virus Human Coronavirus Murine Hepatitis Virus Avian Infectious Bronchitis Virus Murine Coronavirus 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Brian W. J. Mahy
    • 1
  1. 1.Division of Virology, Department of PathologyUniversity of CambridgeEngland

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