The Structure and Behavior of Coronavirus A59 Glycoproteins
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Coronavirus A59 contains three structural proteins. The location of these proteins in relation to the viral envelope and RNA are illustrated in the model shown in Figure 1. A nucleocapsid protein, N, (mw ≃ 50k) forms the nucleocapsid together with the RNA genome. Surrounding the nucleocapsid is a lipoprotein membrane which contains the envelope glycoproteins El (mw ≃ 23k) and E2 (mw ≃180k and 90k). El is an integral membrane protein, the bulk of which lies within the viral membrane and probably spans the lipid bilayer. E2 is a peripheral glycoprotein which forms the characteristic peplomers that are associated with this virion.