Overcoming drug resistance of ovarian carcinoma cell lines by treatment with combination of TNF-α/anti-Fas antibody and chemotherapeutic drugs or toxins

  • B. Bonavida
  • J. T. Safrit
  • H. Morimoto
  • Y. Mizutani
  • S. Yonehara
  • J. S. Berek


Current conventional therapies in the treatment of neoplastic diseases consist of surgery, chemotherapy, radiotherapy and combination therapy. While these forms of treatment have resulted in cures and prolonged survival, recurrent tumors and metastases continue to be very common. Treatment of these recurrent tumors has posed a major challenge to oncologists since these tumors become refractory to chemotherapeutic drugs and metastases are not amenable to surgery or radiotherapy. Thus, the development of tumor cell resistance to cytotoxic drugs has provoked the search for new means to overcome resistance. During the last few years, a surge of new approaches in cancer therapy has emerged that include biological response modifiers to boost the immune response, the use of activated cytotoxic cells such as LAK and TIL and the preparation of ’magic bullets’ consisting of targeted antibody-drug/toxin conjugates, the use of recombinant cytokines (e.g. TNF-α, IFN-γ, IL-2 etc.) and more recently, genetic engineering techniques to modify tumor cells or lymphocytes. Furthermore, new agents to reverse the multidrug resistance phenotype have been considered.


Chemotherapeutic Drug Ovarian Carcinoma Cell Line Overcome Drug Resistance Target Cell Lysis Human Ovarian Carcinoma Cell Line 
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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • B. Bonavida
  • J. T. Safrit
  • H. Morimoto
  • Y. Mizutani
  • S. Yonehara
  • J. S. Berek

There are no affiliations available

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