Cellular DNA content: the most important prognostic factor in patients with borderline tumors of the ovary. Can it prevent overtreatment?

  • J. Kaern
  • C. G. Tropé
  • V. Abeler
  • E. O. Pettersen


The majority of patients with ovarian borderline tumors and invasive carcinoma stage I have excellent prognosis after surgical removal of the tumor. Nevertheless, nearly all of these patients have received adjuvant treatment, in the absence of prognostic factors to pinpoint the few patients at risk, who might benefit from this treatment. Less extended surgery (than the standard surgery performed) might suffice in many patients, thus allowing young women to remain fertile, if more precise prognostic factors could be identified [1–4].


Epithelial Ovarian Cancer Borderline Tumor Pseudomyxoma Peritonei Ovarian Borderline Tumor Complete Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Dembo, A.J., Davy, M., Stenwig, A.E. et al, (1990) Prognostic factors in patients with stage I epithelial ovarian cancer.Obstet. Gynecol,., 75, 263–73.PubMedGoogle Scholar
  2. 2.
    Berek, J.S. (1990) Adjuvant therapy for earlystage ovarian cancer.N. Engl. J. Med., 322, 1076–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Young, R.C., Walton, L.A., Ellenberg, S.S. et al., (1990) Adjuvant therapy in stage I and stage II epithelial ovarian cancer. N. Engl. J. Med., 322,1021–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Finn, C.B., Luesley, D.M., Buxton, E.J. et al., (1992) Is stage I epithelial ovarian cancer overtreated both surgically and systemically? Results of a five-year cancer registry review. Br. J. Obstet. Gynecol., 99, 54–8.CrossRefGoogle Scholar
  5. 5.
    Baak, J.P.A., Langley, F.A., Talerman, A. et al, (1987) The prognostic variability of ovarian tumor grading by different pathologists. Gynecol Oncol., 27,166–72.PubMedCrossRefGoogle Scholar
  6. 6.
    Friedlander, M.L., Russell, P., Taylor, I.W. et al, (1984) Flow cytometric analysis of cellular DNA content as an adjunct to the diagnosis of ovarian tumours of borderline malignancy. Pathology, 16,301–6.PubMedCrossRefGoogle Scholar
  7. 7.
    Kaern, J., Tropé, C., Kjorstad, K.E. et al, (1990) Cellular DNA content as a new prognostic tool in patients with borderline tumors of the ovary. Gynecol Oncol., 38,452–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Hedley, D.W., Friedlander, M.L., Taylor, I.W. et al, (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J. Histochem. Cytochem., 31,1333–5.PubMedCrossRefGoogle Scholar
  9. 9.
    Fossa, S.D., Berner, A., Heiden, T. et al, (1992) DNA ploidy in cell nuclei from paraffinembedded material — comparison of results from two laboratories. Cytometry, 13,395–403.PubMedCrossRefGoogle Scholar
  10. 10.
    Iversen, O.E., Skaarland, E. (1987) Ploidy assessment of benign and malignant ovarian tumors by flow cytometry. A clinicopathologic study. Cancer, 60, 82–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Kühn, W., Kaufmann, M., Feichter, G.E. et al, (1989) DNA flow cytometry, clinical and morphological parameters as prognostic factors for advanced malignant and borderline ovarian tumors. Gynecol Oncol., 33, 360–7.PubMedCrossRefGoogle Scholar
  12. 12.
    Klemi, P.J., Joensuu, H., Mäenpää, J. et al, (1990) Influence of cellular DNA content on survival in ovarian carcinoma.Obstet. Gynecol., 65,200–4.Google Scholar
  13. 13.
    Erhardt, K., Auser, G., Björkholm, E. et al, (1984) Prognostic significance of nuclear DNA content in serous ovarian tumors. Cancer Res., 44,2198–202.PubMedGoogle Scholar
  14. 14.
    Dietel, M., Arps, H., Rohlff, A. et al, (1986) Nuclear DNA content of borderline tumors of the ovary: correlation with histology and significance for prognosis. Virchows Arch. (Pathol Anat.), 409, 829–36.CrossRefGoogle Scholar

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© Chapman & Hall 1995

Authors and Affiliations

  • J. Kaern
  • C. G. Tropé
  • V. Abeler
  • E. O. Pettersen

There are no affiliations available

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