Skip to main content

Alterations in Gastric Mucosal Microvascular Endothelium in a Stressed Condition-Relevance to Gastric Ulcerogenesis

  • Chapter
Vascular Endothelium in Health and Disease

Abstract

Since the pioneering reports of Bergmann1 and Gushing,2 it has been well known that stress greatly influences gastric functions such as acid secretion, blood flow and peristalsis, and is an important factor in the initiation and recurrence of gastric ulcer. A variety of stresses loaded on human and animal body are transmitted to the stomach via the autonomic nervous system,3 which regulates the secretion, microcirculation and motility of the stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Bergmann, Das Spasmogene Ulcus Pepticum, Münch. Med. Wöchenschr., 60:169–174 (1913).

    Google Scholar 

  2. H. Gushing, Peptic ulcers and the interbrain,Surg. Gynecol. Obstet., 55:1–34 (1932).

    Google Scholar 

  3. H. Shay, Stress and gastric acid secretion,Gastroenterology, 26:316–319 (1954).

    PubMed  CAS  Google Scholar 

  4. Y. Yamaguchi, M. Tsuchiya, T. Akiba, K. Kobayashi, K. Shiraishi and H. Nozaki, Experimental studies on the pathological changes in the several organs due to irritation of the autonomic nervous system,Keio J. Med., 9:91–99 (1960).

    Article  Google Scholar 

  5. M. Tsuchiya, T. Shishido, Y. Kamisaka, M. Oda and Y. Fujishiro, The alteration of gastric microcirculation in the restraint-induced gastric lesion, in “Microcirculatory Approach to Current Therapeutic Problems,” Proceedings of the 6th European Conference for Microcirculation, Aalborg, Demmark, 138–141 (1970).

    Google Scholar 

  6. T. Hase and B.J. Moss, Microvascular changes of gastric mucosa in the development of stress ulcer in rats, Gastroenterology, 65:224–234 (1973).

    PubMed  CAS  Google Scholar 

  7. M. Kitajima, R.R. Wolfe, R.L. Trelftadt, J.R. Allsop and J.F. Burk, Gastric mucosal lesion after burninjury: Relationship to Haback diffusion and the microcirculation, J. Trauma, 18:644–650 (1978).

    Article  PubMed  CAS  Google Scholar 

  8. M. Oda, M. Nakamura, N. Watanabe, N. Tsukada, Y. Ohya, E. Sekizuka and M. Tsuchiya, Autonomic nervous regulation of gastric mucosal microcirculation — with special reference to the pathogenesis of stress-induced gastric ulcer, in “Basic Aspects of Microcirculation,” Proceedings of Tokyo International Symposium on Microcirculation, July 26, 1981, Tokyo, Japan, M. Tsuchiya, M. Oda, M. Asano, ed, Excerpta Medica, Amsterdam, 209–229 (1982).

    Google Scholar 

  9. J.D. French, R.W. Porter, F.K.von Amwrongen and R.B. Raney, Gastrointestinal hemorrhage and ulceration associated with intracranial lesions. Surgery, 32:395–407 (1952).

    PubMed  CAS  Google Scholar 

  10. G.J. Tortora, N.P. Anagnostakos, The autonomic nervous system, in “Principles of Anatomy and Physiology,” G.J. Tortora, N.P. Anagnostakos, ed. Harper & Row Publishers, New York, 356–369 (1978).

    Google Scholar 

  11. H. Selye, The physiology and pathology of exposure to stress, A treatise based on the concepts of the general adaptation syndrome and the disease of adaptation. Acta Inc. Medical Publishers, Montreal (1950).

    Google Scholar 

  12. W. Jänig, The autonomic nervous system, in “Human Physiology,” R.F. Schmidt, G. Thews, ed. Springer-Verlag, Berlin, Heiderberg, New York, 111–144 (1983).

    Google Scholar 

  13. M.J. Karnovsky and L. Roots, A direct coloring thiocholine method for Cholinesterase, J. Histochem. Cytochem., 12:219–221 (1964).

    Article  PubMed  CAS  Google Scholar 

  14. M. Nakamura, N. Watanabe, N. Tsukada, M. Oda and M. Tsuchiya, Demonstration of the adrenergic nerves in the rat gastric mucosa — a histofluorescence and electron microscopic study in comparison with the distribution of the cholinergic nerves —, Okajimas Folia Anat. Jpn., 59:65–86 (1982).

    PubMed  CAS  Google Scholar 

  15. M. Oda, M. Nakamura, N. Tsukada, Y. Yonei, H. Komatsu, Y. Ohya, E. Sekizuka and M. Tsuchiya, Dual action of the parasympathetic nerve in the gastric mucosa; significance of its overactivity in the pathogenesis of gastric ulcer, in “Gastronintestinal Function, Regulation and Disturbances,” Proceedings of the 1st Symposium of the Regulation and Disturbances of Gastrointestinal Function, September 18, 1982, Tokyo, Japan, Y. Kasuya, M. Tsuchiya, F. Nagao, Y. Matsuo, ed, Excerpta Medica, Amsterdam, 145–173 (1983).

    Google Scholar 

  16. M. Oda, M. Nakamura, Y. Yonei, K. Kaneko, H. Komatsu, N. Tsukada, K. Honda, Y. Akaiwaand M. Tsuchiya, Features of autonomic innervation of the gastric microvasculature evidence for cholinergic innervation of the mucosal capillaries in the rat stomach —, in “Microcirculation Annual 1985. Japanese Society for Miscrocirculation,” M. Tsuchiya, M. Asano, M. Oda, I. Okazaki, ed, Excerpta Medica, Amsterdam, 205–216 (1985).

    Google Scholar 

  17. M. Nakamura, M. Oda, N. Watanabe, N. Tsukada, Y. Yonei, H. Komatsu, Y. Akaiwa and M. Tsuchiya, Significance of the cholinergic innervation in the gastric mucosa, in “Experimental Ulcer Research Trends in Japan,” Proceedings of the 11th Annual Meeting for Experimental Ulcer Research, November 25, 1983, Tokyo, Japan, M. Tsuchiya, M. Oda, I. Okazaki, ed, Yurinsha Ltd., Tokyo, 127–136 (1984).

    Google Scholar 

  18. B. Falck and N. Hillarp, Fluorescence of cathecolamine and related compounds condensed with folmaldehyde, J. Histochem. Cytochem., 10:348–354 (1973).

    Article  Google Scholar 

  19. V. Ajelis, A. Björklund, B. Falck, O. Lindvall, J. Loren and B. Walles, Application öf the alu minium formaldehyde (ALFA) histofluorescence method for demonstration of peripheral stores of cathecolamines and indolamines in freeze-dried parafine-embedded tissue, cryostat sections and whole mounts. Histochemistry, 65:1–15 (1979).

    Article  PubMed  CAS  Google Scholar 

  20. Y. Matsuo and A. Seki, The coordination of gastrointestinal hormones and the autonomic nerves. Am. J. Gastroenterol., 69:21–50 (1978).

    PubMed  CAS  Google Scholar 

  21. G. Gabella, Innervation of the gastrointestinal tract. Int. Rev. CytoL, 59:129–193 (1979).

    Article  PubMed  CAS  Google Scholar 

  22. I.J. Llewellyn-Smith, J.B. Furness, A.J. Wilson and M. Costa, Organization and fine structure of enteric ganglia,in “Autonomic Ganglia,” L.-G. Elfvin, ed, John Wiley & Sons, Chinchester, 145–182 (1983).

    Google Scholar 

  23. A.P. Evan, W.G. Dail, D. Dammrose and C. Palmer, Scanning electron microscopy of cell surface following removal of extracellular material, Anat. Ree., 185:433–445 (1976).

    Article  CAS  Google Scholar 

  24. T. Fujiwara and Y. Uehara, The cytoarchitecture of the wall and the innervation pattern of the microvessels in the rat mammary grand: a scanning electron microscopic observation. Am. J. Anat., 170:39–54 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. K. Honda, M. Oda, M. Nakamura, N. Tsukada, H. Komatsu, K. Kaneko, T. Azuma and M. Tsuchiya, Involvement of actin filaments in the motility of the primary cultured capillary endothelium, in “Microcirculation Annual 1987. Japanese society for Microcirculation,” M. Tsuchiya, M. Asano, Y. Mishima, ed, Nihon-Igakukan, Tokyo, 117–118 (1987).

    Google Scholar 

  26. M. Oda and K. Honda, Cytoskeletal regulation of endothelial permeability, IVth World Congress for Microcirculation, Symposium, The cell biology of endothelium: permeability, July 27, 1987, Tokyo, Japan.

    Google Scholar 

  27. T. Nagata, T. Nawa and S. Yokota, A new technique for electron microscopic dry-mounting radioautography of soluble compounds, Histoehemie, 18:241–249 (1969).

    Article  CAS  Google Scholar 

  28. M. Nakamura, M. Oda, Y. Yonei, N. Tsukada, N. Watanabe, H. Komatsu and M. Tsuchiya, Demonstration of the localization of muscarinic acetylcholine receptors in the gastric mucosa-light and electron microscopic autoradiographic studies using 3H-quinuclidinyl benzilate. Acta Histochem. Cytochem., 17:297–309 (1984).

    Article  CAS  Google Scholar 

  29. M. Oda, M. Nakamura, Y. Yonei, N. Tsukada, H. Komatsu, K. Kaneko, Y. Akaiwa, E. Ichikawa, I. Okazaki and M. Tsuchiya, Effect of the muscarinic receptor antagonist pirenzepine on the gastric mucosal microcirculation — its possible action sites in the stomach, Proceedings of the Symposium on Pirenzepine: New Aspects in Research and Theraphy, September 18, 1984, Lisbon, Portugal, A. Bettarello, ed, Excerpta Medica, Amsterdam, 19–40 (1985).

    Google Scholar 

  30. K. Honda, M. Oda, M. Nakamura, N. Tsukada, Y. Yonei, H. Komatsu, K. Kaneko, Y. Akaiwa, T. Fujiwara and M. Tsuchiya, Ultrastructural and cytochemical characterization of the monolayer-cultured capillary endothelium, J. Electron Microscopy, 35 (supple):2761–2762 (1986).

    Google Scholar 

  31. H. Komatsu, M. Oda, M. Nakamura, Y. Akaiwa, N. Tsukada, K. Honda, Y. Yonei, K. Kaneko, T. Fujiwara and M. Tsuchiya, Electron microscopic and cytochemical studies on the mechanism of hydrochloric acid secretion — with special reference to actin filaments —, J. Clin. Electron Microscopy, 18:542–543 (1985).

    Google Scholar 

  32. H. Komatsu, M. Oda, K. Honda, K. Kaneko, Y. Yonei, N. Tsukada, M. Nakamura, T. Fujiwara and M. Tsuchiya, Possible involvement of actin filaments in the mechanism of gastric acid secretion — an ultrastructural and immunocytochemical study —, J. Electron Microscopy (supple), 35:2879–2880 (1986).

    Google Scholar 

  33. M. Oda, M. Nakamura, N. Watanabe, N. Tsukada, Y. Yonei, H. Komatsu, K. Kaneko, Y. Akaiwa, I. Okazaki and M. Tsuchiya: Ultrastructural characterization of the microvasculatory system in the stomach-from a terminological point of view-, in “Microcirculation Annual 1985: Japanese Society for Microcirculation,” M. Tsuchiya, M. Asano, M. Oda, I. Okazaki, ed, Excerpta Medica, Amsterdam, 191–204 (1985).

    Google Scholar 

  34. M. Nakamura, M. Oda, N. Watanabe, N. Tsukada, Y. Yonei and M. Tsuchiya, Evidence for direct parasympathetic innervation of parietal cells in the rat glandular stomach-Histochemical and electron microscopic cytochemical study. Folia Okajimas Anat. Jpn., 59:167–179 (1982).

    CAS  Google Scholar 

  35. M. Oda, N. Tsukada, H. Komatsu, Y. Yonei, K. Honda and M. Tsuchiya, Mechanism of contraction and dilatation of sinusoidal endothelial fenestrae in the liver, Hepatology, 6:771 (1986).

    Google Scholar 

  36. G.W. Schmid-Schönbein, S. Usami, R. Skalak and S. Chien, The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels, Microvasc. Res., 19:45–70 (1980).

    Article  PubMed  Google Scholar 

  37. M. Suematsu, S. Miura, M. Suzuki, H. Nagata, T. Morishita, C. Oshio and M. Tsuchiya, 5-lipoxygenaseinhibitor (AA-861) attenuates neutrophil-mediated oxidative stress on the venular endothelium in endotoxemia,J. Clin. Lab. Immunol., 25:41–45 (1988).

    PubMed  CAS  Google Scholar 

  38. Y. Yonei, M. Oda, M. Nakamura, N. Watanabe, N. Tsukada, H. Komatsu, Y. Akaiwa, E. Ichikawa, K. Kaneko, H. Asakura, T. Fujiwara and M. Tsuchiya, Evidence for direct innervation between the cholinergic nerve and mast cells in the rat colonic mucosa. An electron microscopic cytochemical and autoradiographic study, J. Clin. Electron Microscopy, 18:560–561 (1985).

    Google Scholar 

  39. M. Tsuchiya, M. Oda, Y. Kamisaka and C. Oshio, Influence of mast cell degranulation on venular permeability, in “Atherogenesis vol II,” Proceedings of the 2nd international symposium on atherogenesis, thrombogenesis and pyridinolcarbamate treatment. May 18–20, 1972, Tokyo, Japan, T. Shimamoto, F. Numao, G.M. Addison, ed, Excerpta Medica, Amsterdam, 152–158 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Oda, M. et al. (1988). Alterations in Gastric Mucosal Microvascular Endothelium in a Stressed Condition-Relevance to Gastric Ulcerogenesis. In: Chien, S. (eds) Vascular Endothelium in Health and Disease. Advances in Experimental Medicine and Biology, vol 242. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8935-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8935-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8937-8

  • Online ISBN: 978-1-4684-8935-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics