Evidence for a Thromboxane Antagonist in Selected InVitro and InVivo Systems

  • P. E. Malo
  • M. A. Wasserman
  • R. R. Osborn
Part of the NATO ASI Series book series (NSSA, volume 95)


One of the identified products of enzyme action on prostaglandin endoperoxides is the highly unstable thromboxane A2 (TXA2) (Samuelsson et al., 1976). This substance, though short-lived biologically, has effects far exceeding that of either prostaglandin endoperoxide (PGH2 or PGG2) or PGF. As a product of cell membrane-derived arachidonic acid via the cyclooxygenase pathway, TXA2 is produced in tissues and cells of vastly different origin (Table 1). As a result, TXA2 has a number of characteristic actions (e.g., induction of platelet aggregation, contraction of vascular and respiratory smooth muscle and is pro-ulcerogenic/cytodestructive in the GI tract). Additionally, TXA2 action has been shown to be mediated through a discrete class of thromboxane receptors (Jones et al., 1982).


Arachidonic Acid Glyceryl Ether Prostaglandin Endoperoxide Human Platelet Aggregation Meclofenamic Acid 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • P. E. Malo
    • 1
  • M. A. Wasserman
    • 1
  • R. R. Osborn
    • 1
  1. 1.Department of PharmacologySmith Kline and French LaboratoriesPhiladelphiaUSA

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