LTC4 Induces Hyperreactivity of the Isolated Vascular Tissue to Histamine, Serotonin and Norepinephrine

  • L. Daffonchio
  • C. Omini
  • G. Brunelli
  • F. Berti
Part of the NATO ASI Series book series (NSSA, volume 95)


Leukotrienes (LTs) are released from human lung “in vitro” 12 and they exert a potent bronshocontracturating activity in normal and asthmatic subjects3, suggesting an important role for LTs in the allergic bronchoconstriction4. On the other hand anaphylactic shock is accompanied by increase in pulmonary vascular resistance5 and both specific antigen-challenge and LTs “in vitro” induce a vasoconstriction of pulmonary vessels of different animal species6,7. During anaphylactic reaction the vessels of the respiratory system release a considerable amount of LTD4 8,9 and its relative low pharmacological activity10 in this vascular tissue does not rule out a possible interaction with other chemical mediators. All these observations prompted us to investigate the ability of LTs to induce vascular hyperreactivity to other vasoactive compounds. In this regard LTs have been suggested to play a role in the pathogenesis of bronchial hyperreactivity11,12; in addition to this, Creese and Bach13 have shown in guinea-pig tracheal smooth muscle a clear cut potentiating action of LTD4 on histamine and acetylcholine induced contractions.


Contractile Activity Pulmonary Vessel Organ Bath Constrictive Effect Vasoactive Compound 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • L. Daffonchio
    • 1
  • C. Omini
    • 1
  • G. Brunelli
    • 1
  • F. Berti
    • 1
  1. 1.Institute of Pharmacology and PharmacognosyUniversity of MilanItaly

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