The Effect of 9α-Fluorohydrocortisone on the Urinary Excretion of 6-KETO-PGF in Man

  • P. Minuz
  • G. Capuzzo
  • M. Degan
  • C. Lechi
  • G. Covi
  • G. P. Velo
  • A. Lechi
Part of the NATO ASI Series book series (NSSA, volume 95)


The exogenous administration of pharmacological doses of mineralocorticoids causes a transient sodium retention which is followed after a few days by a return to a new sodium balance. This latter phenomenon, known as escape from the sodium-retaining effects of mineralocorticoids, is characterized by an increased urinary volume and sodium excretion. At the same time increased renal blood flow, glomerular filtration rate and reduced renal vascular resistance are observedl. Besides the haemodynamic factors, prostaglandins (PGs) and kallikreinkinin system have been suggested as being responsible, at least partly, for the escape phenomenon.


High Pressure Liquid Chromatography Urinary Volume Sodium Excretion Renal Vascular Resistance Methyl Formate 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • P. Minuz
  • G. Capuzzo
    • 1
  • M. Degan
    • 1
  • C. Lechi
    • 2
  • G. Covi
    • 1
  • G. P. Velo
  • A. Lechi
    • 1
  1. 1.Istituto di Farmacologia, Clinica MedicaUniversità di VeronaItaly
  2. 2.Cattedra di Chimica e Microscopia ClinicaUniversità di VeronaItaly

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