Flavonoids — Lipoxygenases — Platelet Aggregation

  • R. J. Gryglewski
  • J. Robak
  • J. Swięs
Part of the NATO ASI Series book series (NSSA, volume 95)


Flavonoids including flavonols (e.g.quercetin and rutin)are widespread in the plant kingdom and they are concentrated by bees in honey and propolis. Flavonoids interact with many macromolecules in animal cells, change the activity of mammalian enzymes and influence permeability of cell membranes. Controlled trials on the therapeutical efficacy of flavonoids were relatively few, although flavonoids were consistently claimed to show anti-bleeding, anti-thrombotic, anti-inflammatory, anti-allergic, analgesic, cytoprotective, oestrogenic, virusostatic and many other pharmacological actions (Haysteen,1983). In clinical practice, in addition to bioflavonoids, a number of semisynthetic flavonoids has been used.


Arachidonic Acid Platelet Aggregation Platelet Rich Plasma Oxygenase Activity Free Radical Scavenge Property 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. J. Gryglewski
    • 1
  • J. Robak
    • 1
  • J. Swięs
    • 1
  1. 1.Department of PharmacologyN.Copernicus Academy of Medicine in CracowCracowPoland

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