T Cell-Mediated Clearance of JHMV from the Central Nervous System
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Infection with the JHM strain of mouse hepatitis virus (JHMV) results in acute encephalomyelitis accompanied by primary demyelination in the central nervous system (CNS; 1) . Animals that survive show evidence of persistent viral infection in the CNS that is associated with ongoing demyelination (2). Infection of immunocompromised animals suggests that the immune response is important not only in survival, but also as a determinant of whether the infection is cleared or progresses to become persistent. We initially demonstrated that the addition of anti-viral antibody to in vitro cultures of cells persistently infected with JHMV stopped the release of infectious virus (3,4). These in vitro data suggested that anti-viral antibody might play an important role in the ability of JHMV to establish a persistent infection in the CNS. Subsequent work has demonstrated that the passive transfer of monoclonal antibodies specific for all three structural proteins prevents death due to acute infection (5,6,7,8). Two very surprising findings were made. First, none of the transferred antibodies inhibited the replication of the virus in the CNS.
KeywordsMouse Hepatitis Virus Nylon Wool Antiviral Antibody Murine Coronavirus Immunocompromised Animal
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