Mouse Hepatitis Virus 3 Pathogenicity and B and T Lymphotropisms

  • Pierre Jolicoeur
  • Lucie Lamontagne
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


Viral pathogenicity may be regulated by a host defense mechanism during virus-cell interaction at the immune system level. When the virus is lymphotropic, understanding the pathogenic process of the viral disease is complicated by the virus-lymphocyte interaction which may alter the integrity of the cell and induce a subsequent immunodeficiency.


Bone Marrow Viral Pathogenicity Cell Depletion Cell Subpopulation Thymic Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Piazza, M., F. Piccinino, and F. Matano. 1965. Haematologic changes in viral (MHV3) murine hepatitis. Nature205: 1034.CrossRefGoogle Scholar
  2. 2.
    LePrevost, C., E. Levy-Leblond, J.L. Virelizier, and J.M. Dupuy. 1975. Immunopathology of mouse hepatitis virus type 3 infection. I. Role of humoral and cell-mediated immunity in resistance mechanisms. J. Immunol. 114: 221.PubMedGoogle Scholar
  3. 3.
    Dupuy, J.M., E. Levy-Leblond, and C. LePrevost. 1975. Immunopathology of mouse hepatitis virus type 3 infection. II. Effect of immunosuppression in resistant mice. J. Immunol. 114: 226.PubMedGoogle Scholar
  4. 4.
    Tardieu, M., C. Hery, and J.M. Dupuy. 1980. Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance. J. Immunol. 124: 418.PubMedGoogle Scholar
  5. 5.
    Dupuy, J.M., C. Dupuy, and D. Décarie. 1984. Genetically-determined resistance to mouse hepatitis virus 3 expressed in hematopoietic donor cells in radiation chimeras. J. Immunol. 133: 1609.PubMedGoogle Scholar
  6. 6.
    Osmond, D.G., and G.V.J. Nossal. 1974. Differencial on of lymphocytes in mouse bone marrow. II. Kinetics of maturation and renewal of antiglobulin binding cells studied by double labeling. Cell . Immunol. 13: 137.Google Scholar
  7. 7.
    Raff, M.C., and Owen, J.J.T. 1971. Thymus derived lymphocytes: their distribution and role in the development of peripheral lymphoid tissues of the mouse. Eur. J. Immunol. 1: 27.PubMedCrossRefGoogle Scholar
  8. 8.
    Collins, S.W., and J.S. Portefield. 1986. A new mechanism for the neutralization of enveloped viruses by antiviral antibody. Nature321: 244.CrossRefGoogle Scholar
  9. 9.
    Borysiewicz, L.K., and J.G.P. Sissons. 1986. Immune response to virus infected cells. Clin. Immunol. Allergy6: 159.Google Scholar
  10. 10.
    Sissons, J.P.G., R.D. Schreiber, N.R. Couper, and M.B.A. Oldstone. 1982. The role of antibody and complement in lysing virus-infected cells. Med. Microbiol. Immunol. 170: 221.PubMedCrossRefGoogle Scholar
  11. 11.
    Krystyniak, K., and J.M. Dupuy. 1981. Early interaction between mouse hepatitis virus 3 and cells. J. Gen. Virol. 57: 53.CrossRefGoogle Scholar
  12. 12.
    Leray, D., C. Dupuy, and J.M. Dupuy. 1982. Immunopathology of mouse hepatitis virus type 3 infection. IV. MHV3-induced immunodepression. Clin. Immunol. Immunopathol. 23: 223.CrossRefGoogle Scholar
  13. 13.
    Lamontagne, L., C. Dupuy, D. Leray, J.P. Chausseau, and J.M. Dupuy. 1985. Coronavirus-induced immunosuppression: Role of mouse hepatitis virus 3-lymphocyte interaction. Prog. Leuk. Biol. 1: 29.Google Scholar
  14. 14.
    Dupuy, J.M., and D. Rodrigue. 1981. Heterogeneity in evolutive pattern of inbred mice infected with a cloned substrain of mouse hepatitis virus type 3. Intervirology16: 116.CrossRefGoogle Scholar
  15. 15.
    Lamontagne, L., and J.M. Dupuy. 1984. Persistent in vitro infection with mouse hepatitis virus type 3 in mouse lymphoid cell lines. Infect. & Immun. 44: 716.Google Scholar
  16. 16.
    Wysocki, L.J., and V.L. Sato. 1978. Panning for lymphocytes: a method for cell selection. Proc. Natl . Acad. Sci. USA75: 2844.PubMedCrossRefGoogle Scholar
  17. 17.
    Park, Y.H., and D.G. Osmond. 1987. Phenotype and proliferation of early B lymphocyte precursor cells in mouse bone marrow. J. Exp. Med. 165: 444.PubMedCrossRefGoogle Scholar
  18. 18.
    Lamontagne, L., J.P. Descoteaux, and P. Jolicoeur. 1989. Mouse hepatitis virus 3 replication in T and B lymphocytes correlate with viral pathogenicity. J. Immunol. 142: 4458.PubMedGoogle Scholar
  19. 19.
    Lamontagne, L., D. Decarie, and J.M. Dupuy. 1989. Host cell resistance to mouse hepatitis virus type 3 is expressed in vitro in macrophages and lymphocytes. Viral Immunol. 2: 37.PubMedCrossRefGoogle Scholar
  20. 20.
    Levy-Leblond, E., D, and J.M. Dupuy. 1979. Genetic study of mouse sensitivity to MHV3 infection: influence of the H-2 complex. J. Immunol. 112: 1359.Google Scholar
  21. 21.
    LePrevost, C., J.L. Virelizier, and J.M. Dupuy. 1975. Immunopathology of mouse hepatitis virus type 3. III. Clinical and virologic observations of a persistent viral infection. J. Immunol.115: 640.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Pierre Jolicoeur
    • 1
  • Lucie Lamontagne
    • 1
  1. 1.Département des Sciences BiologiquesUniversité du Québec à MontréalMontréalCanada

Personalised recommendations