Background Paper Mapping Epitopes on Coronavirus Glycoproteins
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The purpose of this paper is to summarise the state of Coronavirus epitope research, with an emphasis laid on the most recent achievements, i.e. the correlation between antigenicity and polypeptide primary structure. The antigenic properties of coronaviruses reside mainly in their envelope glycoproteins: the S (spike) protein, a high molecular weight polypeptide which constitutes the petal-shaped peplomers and the M (membrane) protein, a smaller integral membrane polypeptide. Some coronaviruses possess an additional surface glycoprotein, the haemagglutinin-esterase (HE) protein.
KeywordsInfectious Bronchitis Virus Escape Mutant Protein Recombinant Virus High Molecular Weight Polypeptide Major Antigenic Site
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