Background Paper Mapping Epitopes on Coronavirus Glycoproteins

  • Hubert Laude
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 276)


The purpose of this paper is to summarise the state of Coronavirus epitope research, with an emphasis laid on the most recent achievements, i.e. the correlation between antigenicity and polypeptide primary structure. The antigenic properties of coronaviruses reside mainly in their envelope glycoproteins: the S (spike) protein, a high molecular weight polypeptide which constitutes the petal-shaped peplomers and the M (membrane) protein, a smaller integral membrane polypeptide. Some coronaviruses possess an additional surface glycoprotein, the haemagglutinin-esterase (HE) protein.


Infectious Bronchitis Virus Escape Mutant Protein Recombinant Virus High Molecular Weight Polypeptide Major Antigenic Site 
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Selected Literature

  1. Cavanagh, D., Davis, P.J. and Mockett, A.P.A. (1988) Amino acids within hypervariable region 1 of avian Coronavirus IBV (Massachusetts serotype) spike glycoprotein are associated with neutralisation epitopes. Virus Res., 11: 141–150.PubMedCrossRefGoogle Scholar
  2. Lenstra, J.A., Kusters, J.G., Koch, G. and van der Zeijst, B.A.M. (1989) Antigenicity of the peplomer protein of infectious bronchitis virus. Mol. Immunol., 26: 7–15.PubMedCrossRefGoogle Scholar
  3. Lutyes, W., Geerts, D., Posthumus, W., Meloen, R. and Spaan, W. (1989) Amino acid sequence of a conserved neutralising epitope of murine coronaviruses. J. Virol., 63: 1408–1412.Google Scholar
  4. Makino, S., Fleming, J.O., Keck, J.G., Stohlman, S.A. and Lai, M.M.C. (1987) RNA recombination of coronaviruses: localisation of neutralising epitopes and neuropathogenic determinants on the carboxy terminus of peplomers. Proc. Natl. Acad. Sci. USA. 84: 6567–6571.PubMedCrossRefGoogle Scholar
  5. Talbot, P.J., Dionne, G. and Lacroix, M. (1988) Vaccination against lethal coronavirus-induced encephalitis with a synthetic decapeptide homologous to a domain in the predicted peplomer stalk. J. Virol., 62: 3032–3036.PubMedGoogle Scholar
  6. Tooze, S.A., and Stanley, K.K. (1986) Identification of two epitopes in the carboxyterminal 15 amino acids of the El glycoprotein of mouse hepatitis virus A%9 by using hybrid proteins. J. Virol. 60: 928–934.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hubert Laude
    • 1
  1. 1.Station de Recherches de Virologie et d’Immunologie MoléculairesInstitut National de la Recherche AgronomiqueJouy-en-JosasFrance

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