The Influence of Liver-Bypass on Transport and Compartmentation InVivo

  • Jill E. Cremer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 69)


In this paper consideration will be given to the transport of metabolizeable molecules and their transformation once they have entered the brain from the blood. Few studies on uptake processes have also followed the rapidity with which some substances can be transformed by established enzymic pathways. Furthermore, even substrates undergoing certain metabolic sequences in common, such as the formation and oxidation of acetyl-CoA, appear to do so in a non-uniform manner. This may indicate a “directed” movement of small molecules to specific sites for metabolism. This could be into particular types of cells or into discrete parts of the same cell type.


Monocarboxylic Acid Tritiated Water Lateral Tail Vein Acetate Butyrate Radioactivity Ratio 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Jill E. Cremer
    • 1
  1. 1.Medical Research Council LaboratoriesM.R.C. Toxicology UnitCarshaltonUK

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