The Influence of Liver-Bypass on Transport and Compartmentation InVivo
In this paper consideration will be given to the transport of metabolizeable molecules and their transformation once they have entered the brain from the blood. Few studies on uptake processes have also followed the rapidity with which some substances can be transformed by established enzymic pathways. Furthermore, even substrates undergoing certain metabolic sequences in common, such as the formation and oxidation of acetyl-CoA, appear to do so in a non-uniform manner. This may indicate a “directed” movement of small molecules to specific sites for metabolism. This could be into particular types of cells or into discrete parts of the same cell type.
KeywordsMonocarboxylic Acid Tritiated Water Lateral Tail Vein Acetate Butyrate Radioactivity Ratio
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