Brain Damage and Oral Intake of Certain Amino Acids
The primary focus in this chapter will be on glutamate (GLU) and certain of its structural analogues which I shall refer to as the excitotoxic amino acids because of specific neuroexcitatory and neurotoxic properties which characterize these acidic amino acids as a group. Brief attention will be given separately to L-cysteine (CYS) which, when given orally to experimental animals, induces a different neurotoxic syndrome from that caused by oral intake of excitotoxic amino acids. Most of the evidence I shall review pertains to excitotoxic amino acids as a group but derives from studies on GLU, the prototypic and most studied member of the group.
KeywordsBrain Damage Arcuate Nucleus Lower Effective Dose Monosodium Glutamate Venezuelan Equine Encephalitis Virus
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