Transport of Adenine Derivatives in Tissues of the Brain
It will be valuable first to note the ubiquity of adenine derivatives in the brain and some of the effects which can be ascribed to the appearance in extracellular fluids of a small proportion of the tissue’s adenine compounds. Adenine derivatives are prominent components of the small molecular-weight metabolites of the cells of the brain, and also of important categories of their macromolecules, especially of the nucleic acids. Because adenine nucleotides are associated with energy-metabolism, almost all changes in cerebral activities are to some degree associated with changes — of place or of chemical nature or both — in cerebral adenine derivates. The converse is also true; several adenine derivatives when administered to animals alter their behavior in fashions which can be ascribed to changes in cerebral functioning. Examples are quoted in Table 1, which lists also the effects of applying an adenine derivative directly to the mammalian brain and to preparations derived from it.
KeywordsAdenine Nucleotide Adenylate Kinase Cerebral Tissue Piriform Cortex Electrical Excitation
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