Evaluation of an Experimental Anticholinergic Drug, Elantrine, in Treating the Tremor of Parkinsonism

  • Alvin Rix
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 90)


An experimental anticholinergic drug, elantrine, had shown sig nificant improvement in tremor of parkinsonism in 89 patients not taking L-dopa. A double-blind study of 22 parkinsonian patients stabilized on L-dopa showed marked improvement in tremor and moderate improvement in rigidity and bradykinesia when elantrine was added to their treatment program. Nine of 15 patients taking L-dopa (or Sinemet®) and elantrine had cessation of all tremor and have continued free of tremor to date, over two years.


Multiple Sclerosis Essential Tremor Methyl Dopa Parkinsonian Patient Placebo Patient 
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  3. Hoehn, M.M. and Yahr, M.D. (1967) Parkinsonism: onset, progression and mortality. Neurology 17, 427–442.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Alvin Rix
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Oklahoma School of MedicineOklahoma CityUSA

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