Oral Contraceptives and Excess Mortality From Venous and Pulmonary Thromboembolism in the United States

  • Daniel G. Seigel
  • Robert E. Markush


Analysis of trends in mortality from thromboembolic disorders in women in the reproductive ages was motivated by two types of information. The first is that the proportion of women who are using oral contraceptives is large, estimated in a national survey in 1965 to be 15% of married women under age 45 (1). The second is that the risk of death from pulmonary embolism or cerebral thrombosis has been reported to be increased by a factor of 8 in these women (2). The combination of a large proportion of oral contraceptive users with such an increased risk should produce a doubling in the overall national mortality from these causes for women in the childbearing ages.


Oral Contraceptive Annual Percent Change Pulmonary Thromboembolism Mortality Trend Oral Contraceptive User 
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  1. 1.
    Ryder, N. B., and Westoff, C. F.: Use of oral contraception in the United States, 1965. Science 153:1199–1205 (Sept 9) 1966.PubMedCrossRefGoogle Scholar
  2. 2.
    Irnnan, W. H. W., and Vessey, M. P.: Investigation of deaths from pulmonary, coronary, and cerebral thrombosis and embolism in women of child-bearing age, Brit. Med. J. 2:193–199 (April 27) 1968.CrossRefGoogle Scholar
  3. 3.
    Markush, Robert E., and Seigel, Daniel G.: Oral contraceptives and mortality trends from thromboembolism in the United States. Amer. J, Public Health (In Press).Google Scholar
  4. 4.
    Seigel, Daniel G., and Markush, Robert E.: Oral contraceptives and relative risk of death from venous and pulmonary thromboembolism in the United States. Submitted for publication.Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • Daniel G. Seigel
    • 1
  • Robert E. Markush
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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