Effects of Estrogens and Progesterones on Collagen Metabolism

  • Stephen M. Krane


In attempting to evaluate effects of estrogens and progestational compounds on bone, it is important to consider how the components of the organic matrix may be affected. Bone consists of an inorganic mineral phase, which comprises approximately two thirds of the weight of the tissue, and an organic phase which is largely the protein collagen. Today I shall discuss selected studies on the effects of estrogens and progesterones on metabolism of collagen not only in bone but in other connective tissues as well. It is necessary, however, to review briefly some aspects of the chemistry and biology of collagen (1,2) in order to evaluate the results of such studies.


Collagen Synthesis Bone Collagen Collagen Metabolism Label Amino Acid Soluble Collagen 
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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • Stephen M. Krane
    • 1
  1. 1.Departments of MedicineHarvard Medical School and Massachusetts General HospitalBostonUSA

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