Effects of Estrogens and Progesterones on Collagen Metabolism
In attempting to evaluate effects of estrogens and progestational compounds on bone, it is important to consider how the components of the organic matrix may be affected. Bone consists of an inorganic mineral phase, which comprises approximately two thirds of the weight of the tissue, and an organic phase which is largely the protein collagen. Today I shall discuss selected studies on the effects of estrogens and progesterones on metabolism of collagen not only in bone but in other connective tissues as well. It is necessary, however, to review briefly some aspects of the chemistry and biology of collagen (1,2) in order to evaluate the results of such studies.
KeywordsCollagen Synthesis Bone Collagen Collagen Metabolism Label Amino Acid Soluble Collagen
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