Effect of Estrogens on the Structure of Bone
The effects of estrogens on the bone of fowl, immature mice and immature rats are dramatic. In chicks, estrogen causes formation of new bone originating from the endosteal surfaces and eventually almost filling the marrow cavity with trabeculae (1). In normal fowl this is a cyclical phenomenon related to the estrous cycle but can be produced in cockerels by administering estrogen. A superficially similar growth of new bone, primarily in the metaphysis, but extending into the diaphysis, can be caused in mice by pharmacological doses of estrogens (2). This effect is not observed normally and the doses of estrogens used are sufficient to inhibit body growth. Simmons (3) and Uelinger (4) both have measured the uptake of triated thymadine in preosteoblasts after a flash label and found it to be significantly accelerated, indicating an increase proliferation of these cells as a result of treatment with estrogens. Testosterone appears to inhibit or reverse this action of estrogens, possibly by accelerating bone resorptive activity (5).
KeywordsBone Formation Bone Mass Bone Resorption Estrogen Deficiency Pharmacological Dose
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- 3.Simmons, D. J. Cellular changes in the bones of mice as studied with triated thymidine and the effects of estrogen. Clin. Orthopaed. 26,176, (1963).Google Scholar
- 4.Uehlinger, E. On the influence of thyroxine, thiouracil, l cortisone, estrogen and testosterone on endochondral ossification utilizing autoradiography, in Calcified Tissues 1965, H. Fleisch, H. J.J. Blackwood and M. Owen, eds. Springer-Verlog, New York, (1966) p. 243.Google Scholar
- 11.Garn, S. M., Rohmann, C. G. and Nolan, P., Jr. The developmental nature of bone changes during aging in Relations of Development and Aging. J. E. Burren, ed. G.G. Thomas, Springfield, III. (1964).Google Scholar
- 12.Arnold, J. S., Bartley, M. H., Tont, S.A. and Jenkins, D. P. Skeletal changes in aging and disease. Clin. Orthopaed. 49, 17 (1966).Google Scholar
- 13.Jasani, C., Nordin, B. E. G., Smith, D. A. and Swanson, I. Spinal osteoporosis and the menopause, Proc. Royal Soc. Med. 58, 441 (1965).Google Scholar
- 14.Meema, H. E. Menopausal and aging changes in muscle mass and bone mineral content. J. Bone and Joint Surg. 48 A, 1138 (1966).Google Scholar
- 15.Smith, R. W., Jr. Dietary and hormonal factors in bone loss. Federation Proc. 26, 1737 (1967).Google Scholar
- 16.Baylink, D. J., Vose, G. P., Dotter, W. E. and Hurxthal, L. M. Two new methods for the study of osteoporosis and other metabolic bone disease. II. Vertebral bone densitometry. Lahey Glin. Bull. 13, 217 (1964).Google Scholar
- 19.Albright, F., and Reifenstein, E.G., Jr. The Parathyroid Glands and Metabolic Bone Disease: Selected Studies. (1948) Williams & Wilkins Gompany, Baltimore.Google Scholar
- 23.Jowsey, J., Kelly, P. J., Riggs, B. L., Bianco, A. J., Jr., Scholz, D. A., and Gershon-Cohen, J. Quantitative micro- radiographic studies of normal and osteoporotic bone. J. Bone Joint Surg. 47A, 785 (1965).Google Scholar
- 26.Riggs, B. L., Jowsey, J. and Kelly, P.J. Effect of sex hormones on bone metabolism in primary osteoporosis. Clin. Res. 16, 468 (1968).Google Scholar