Effects of Estrogen on Calcium Metabolism in Man
Scientific interest in a relationship between gonadal steroids and bone mineral metabolism began when the rapid changes of bone structure that occur during egg-laying in the pigeon were recorded in 1934 (1). As the egg approaches maturity bone formation in the tibias and femurs becomes so intense that these bones become almost solid. This mass of bone is suddenly and rapidly resorbed as calcification of the shell begins. These changes were shown, by classic endocrine studies, to be secondary to cyclic changes in estrogen secretion (2). Similar observations in diverse species, such as chickens, mice, rats, and pocket gophers, showed that gonadal hormones have a variety of effects on bone, including stimulation and inhibition of both bone growth and resorption, as well as no effect.
KeywordsBone Formation Bone Resorption Calcium Metabolism Metabolic Bone Disease Ethinyl Estradiol
Unable to display preview. Download preview PDF.
- 2.Gardner, W.U., and C.A. Pfeiffer: Influence of estrogens and androgens on skeletal system. Physiol Rev 23:139–165 (1943).Google Scholar
- 3.Albright, F., and E.G. Reifenstein, Jr.: The Parathyroid Glands and Metabolic Bone Disease. Williams and Wilkins, Baltimore, Maryland (1948)Google Scholar
- 7.Parfitt, A.M.: Changes in serum calcium and phosphorus during stilbestrol treatment of osteoporosis. J Bone Joint Surg 47b:137–139 (1965).Google Scholar
- 11.Isakkson, B., and B. Sjögren: Errors inherent in metabolic balance studies. Excerpta Med Intern Congr Series No. 83, Vol. II. 1965, p. 1041–1049.Google Scholar
- 14.Jowsey, J., P.J. Kelly, B.L. Riggs, A.J. Bianco, D.A. Scholz, and J. Gershon-Cohen: Quantitative microradiographic studies of normal and osteoporotic bone. J Bone Joint Surg 47a:785–806 (1965).Google Scholar
- 15.Taylor, T.C., B.N. Epker, and H.M. Frost: The appositional rate of Haversian and endosteal bone formation measured in tetracycline labeled human ribs. J Lab Clin Med 67:633–639 (1966).Google Scholar
- 17.Eisenberg, E.: Effect of steroids on calcium djmamics. In Biological Activities of Steroids in Relation to Cancer. G. Pincus and E.P. Vollmer, eds. New York, Academic Press. 1960, p.189–197.Google Scholar
- 19.Riggs, B.L., J. Jowsey, and P.J. Kelly: Effect of sex hormones on bone metabolism in primary osteoporosis. Clin Res 16:468 (1968).Google Scholar