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Properties and Origin of Uterine Renin

  • P. J. Mulrow
  • T. F. Ferris
  • P. Gordon
  • R. C. Anderson
  • P. N. Herbert

Abstract

For many years, renin has been considered to be an enzyme that is synthesized and stored in the juxtaglomerular apparatus of the kidney. Recently, substantial quantities of renin have been extracted from the salivary gland of the white mouse and from the pregnant rabbit uterus and placenta (1–3). In view of the recent reports of high concentrations of renin in the plasma and amniotic fluid of pregnant women, this finding takes on special significance (4,5). The present report summarizes some of our studies on rabbit uterine renin that have been published in more detail elsewhere (6–8).

Keywords

Amniotic Fluid Plasma Renin Activity Disc Electrophoresis Juxtaglomerular Apparatus Human Amniotic Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bing, J. and Faarup, P.: Location of renin (or a renin- like substance) in the submaxillary glands of albino mice. Acta Path. Microbiol. Scand. 65:203–212 (1965).Google Scholar
  2. 2.
    Bing, J. and Faarup, P.: Location and site of formation of extrarenal renin, in International Club on Arterial Hypertension, L’Expansion Seientifique Francaise, Paris, 1966, p. 75–80.Google Scholar
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    Gross, F., Schaechtelin, G., Ziegler, M. and Berger, M.: A renin-like substance in the placenta and uterus of the rabbit. Lancet 1:914–916 (1964).PubMedCrossRefGoogle Scholar
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    Gorden, P., Ferris, T.F. and Mulrow, P.J.: Rabbit uterus as a possible site of renin synthesis. Am. J. Physiol. 212;703–706 (1967).PubMedGoogle Scholar
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    Anderson, R.C., Herbert, P.N. and Mulrow, P.J.: A comparison of properties of renin obtained from the kidney and uterus of the rabbit. Am. J. Physiol. 215:774–778 (1968).PubMedGoogle Scholar
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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • P. J. Mulrow
    • 1
  • T. F. Ferris
    • 1
  • P. Gordon
    • 1
  • R. C. Anderson
    • 1
  • P. N. Herbert
    • 1
  1. 1.Department of Internal MedicineYale University School of MedicineNew HavenUSA

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