Studies on the Mechanism of Hypertriglyceridemia Induced by Oral Contraceptives

  • W. R. Hazzard
  • M. J. Spiger
  • E. L. Bierman


We have heard convincing evidence this morning of the alterations in plasma lipids induced by a broad range of oral contraceptive preparations. Because of the epidemiological association between atherosclerotic cardiovascular disease and hyperlipoproteinemia, hypertriglyceridemia as well as hypercholesterolemia (1), and the possibility that progestational agents may therefore limit the relative immunity from atherosclerosis enjoyed by premenopausal women, we have begun to explore the mechanism of the hypertriglyceridemia of oral contraceptive therapy. These studies, then, evaluate the altered balance between triglyceride (TG) input and removal which result in a raised plasma TG concentration in women given oral progestational agents.


Oral Contraceptive Lipoprotein Lipase Ethinyl Estradiol Oral Contra Oral Contraceptive Therapy 
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Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • W. R. Hazzard
    • 1
  • M. J. Spiger
    • 1
  • E. L. Bierman
    • 1
  1. 1.Department of MedicineUniversity of Washington School of MedicineWashingtonUSA

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