Advertisement

Studies on the Mechanism of Hypertriglyceridemia Induced by Oral Contraceptives

  • W. R. Hazzard
  • M. J. Spiger
  • E. L. Bierman

Abstract

We have heard convincing evidence this morning of the alterations in plasma lipids induced by a broad range of oral contraceptive preparations. Because of the epidemiological association between atherosclerotic cardiovascular disease and hyperlipoproteinemia, hypertriglyceridemia as well as hypercholesterolemia (1), and the possibility that progestational agents may therefore limit the relative immunity from atherosclerosis enjoyed by premenopausal women, we have begun to explore the mechanism of the hypertriglyceridemia of oral contraceptive therapy. These studies, then, evaluate the altered balance between triglyceride (TG) input and removal which result in a raised plasma TG concentration in women given oral progestational agents.

Keywords

Oral Contraceptive Lipoprotein Lipase Ethinyl Estradiol Oral Contra Oral Contraceptive Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Albrink, M.J.: Triglycerides, lipoproteins, and coronary artery disease. Arch. Int. Med. 109:345–359 (1962).CrossRefGoogle Scholar
  2. 2.
    Fabian, E., Stork, A., Kobilkova, J., and Sponarova, J.: The activity of the lipoprotein lipase and estrogens. Enzym. Biol. Clin. 8:45–455 (1967).Google Scholar
  3. 3.
    Sandhofer, F., Sailer, S., Braunsteiner, H. and Braitenberg, H.: Post-heparin lipoproteinlipase and Schwangerschaft. Wien. Klin. Wschr. 73:392–393 (1961).PubMedGoogle Scholar
  4. 4.
    Otway, W., and Robinson, D.S.: The significance of changes in tissue clearing-factor lipase activity in relation to the lipemia of pregnancy. Biochem. J. 106:677–682 (1968).PubMedGoogle Scholar
  5. 5.
    Bagdade, J.D., Porte, D., Jr., and Bierman, E.L.: Diabetic lipemia: a form of acquired fat-induced lipemia. New Eng. J. Med. 276:427–433 (1967).PubMedCrossRefGoogle Scholar
  6. 6.
    Bagdade, J.D., Porte, D., Jr. and Bierman, E.L.: Acute insulin withdrawal and the regulation of plasma triglyceride removal in diabetic subjects. Diabetes 17:127–132 (1968).PubMedGoogle Scholar
  7. 7.
    Porte, D., Jr., O’Hara, D.D. and Williams, R.H.: The relation between postheparin lipolytic activity and plasma triglyceride in myxedema. Metabolism 15:107–113 (1966).PubMedCrossRefGoogle Scholar
  8. 8.
    Fredrickson, D.S., Ono, K., and Davis, L.L.: Lipolytic activity of post-heparin plasma in hypertriglyceridemia. J. Lipid Res. 4:24–33 (1963).PubMedGoogle Scholar
  9. 9.
    Fredrickson, D.S., Levy, R.I. and Lees, R.S.: Fat transport in lipoproteins—an integrated approach to mechanisms and disorders. Part III. New Eng. J. Med. 276:148–156 (1967).PubMedCrossRefGoogle Scholar
  10. 10.
    Harlan, W.R., Winesett, P.S. and Wasserman, A.J.: Tissue lipoprotein lipase in normal individuals and individuals with p exogenous hypertriglyceridemia and the relationship of this enzyme to assimilation of fat. J. Clin. Invest. 46:239–247 (1967).PubMedCrossRefGoogle Scholar
  11. 11.
    Riggs, D.S.: The Mathematical Approach to Physiological, Problems, Williams and Wilkins Co., Baltimore, 1963, Chapter 11, pp 272–298.Google Scholar
  12. 12.
    Robinson, D.S.: The clearing factor lipase and its action in the transport of fatty acids between the blood and the tissues. Adv. Lipid Res. 11: 133–182 (1963).Google Scholar
  13. 13.
    Farquhar, J.W., Frank, A., Gross, R.C. and Reaven, G.M.: Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man. J. Clin. Invest. 45:1648–1656 (1966).PubMedCrossRefGoogle Scholar
  14. 14.
    Bierman, E.L. and Porte, D., Jr.: Carbohydrate intolerance and lipemia. Ann. Int. Med. 68:926–933 (1968).PubMedGoogle Scholar
  15. 15.
    Bagdade, J.D., Porte, D., Jr. and Bierman, E.L.: Hypertriglyceridemia: a metabolic consequence of chronic renal failure. New Eng. J. Med. 279: 181–185 (1968).PubMedCrossRefGoogle Scholar
  16. 16.
    Ford, S., Bozian, R.C. and Knowles, H.C.: Interactions of obesity, and glucose and insulin levels in hypertriglyceridemia. Amer. J. Clin Nutr. 21:904–910 (1968).PubMedGoogle Scholar
  17. 17.
    Spellacy, W.N., Carlson, K.L., Burk, S.A., and Schade, S.L.: Glucose and insulin alterations after one year of combination-type oral contraceptive treatment. Metabolism 17:496–501 (1968).PubMedCrossRefGoogle Scholar
  18. 18.
    Bagdade, J.D.: Basal insulin and obesity. Lancet ii,: 630–631 (1968).CrossRefGoogle Scholar
  19. 19.
    Spellacy, W.N., Carlson, K.L. and Schade, S.L.: Human growth hormone levels in normal subjects receiving an oral contraceptive. J. Amer. Med. Assoc. 2: 115–118 (1967).Google Scholar

Copyright information

© Plenum Press, New York 1969

Authors and Affiliations

  • W. R. Hazzard
    • 1
  • M. J. Spiger
    • 1
  • E. L. Bierman
    • 1
  1. 1.Department of MedicineUniversity of Washington School of MedicineWashingtonUSA

Personalised recommendations