Oral Contraceptives, Lipoproteins, and Lipid Transport
More than twenty-five years have elapsed since the obvious sex difference in the prevalence of atherosclerosis before age 50 led to the widely held view that gonadal hormones might affect plasma lipids and hence influence the progression of atherosclerosis. Further understanding awaited the development of methods of analysis of the actual transport forms of lipid molecules in plasma, the lipoproteins. A major insight into the problem was provided by Russ, Eder and Barr (1) with the use of the precipitation method of fractionation of lipoproteins into two major classes, “alpha” and “beta” lipoproteins. By measurement of the cholesterol content of these fractions they found that plasma from young women contained more “alpha lipoprotein” and less “beta lipoprotein” than that from men of comparable age. They also found that estrogen treatment of males tended to eliminate this difference by decreasing the “beta/alpha ratio”.
KeywordsOral Contraceptive High Density Lipoprotein Gonadal Steroid Gonadal Hormone Lipoprotein Fraction
Unable to display preview. Download preview PDF.
- 4.Nikkila, E.: Studies on the lipid-protein relationships in normal and pathological sera and the effect of heparin on serum lipoproteins. Scand. J. Clin. & Lab. Invest. 5 (Suppl. 8) 1–101 (1953).Google Scholar
- 6.Marshall, N.B.: Gonadal hormones and lipid metabolism. In Lipid Pharmacology, ed. by R. Paoletti. (Chapter 8) Academic Press, New York, 1964.Google Scholar
- 14.Furman, R.H., Alaupovic, P. and Howard, R.P.: Effects of androgens and estrogens on sertm lipids and the composition and concentration of serum lipoproteins in normolipemic and hyperlipi- demic states. Progr. Biochem. Pharmacol. 2:215–249 (1967).Google Scholar
- 15.Pincus, Gregory: The Control of Fertility. Academic Press, New York, 1965., pp. 276–277.Google Scholar
- 24.Fabian, E., Stork, A., Kobilkova, J. and Sponarova, J.: The activity of the lipoprotein lipase and estrogens. Enzym. Biol. Clin. 8:451–455 (1967).Google Scholar
- 25.Sandhofer, von F., Sailer, S., Braunsteiner, H. and Braitenberg, H.: Post-heparin lipoproteinlipase und Schwangerschaft. Untersuchunger über die lipoproteinlipase II. 73:392–393 (1961).Google Scholar