Coronaviruses pp 521-527 | Cite as

Relatedness of Rabbit Coronavirus to Other Coronaviruses

  • J. David Small
  • Robert D. Woods
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


Rabbit coronavirus (RbCV) was apparently first encountered in 1961 when Scandinavian investigators observed occasional mortality in rabbits used to propagate the Nichols strain of Treponema pallidum. Mortality rates reached 50 percent by 1968 and 75 percent by 1970. Contaminated samples of T. pallidum were brought to the Johns Hopkins University School of Medicine, a World Health Organization center for the study of treponema-toses. There it was established that the causative agent was filterable, the heart was the target organ, and the agent was determined by electron microscopy to be a coronavirus. Also, complement fixing antibodies to the human coronaviruses 229E (two way cross) and OC43 (one way cross) were demonstrated in surviving rabbits. Immunofluorescent staining with anti-229E serum localized fluorescence in the interstitial tissue of the myocardium.


Feline Infectious Peritonitis Hyperimmune Serum Human Coronavirus Plaque Reduction Assay Transmissible Gastroenteritis Virus 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. David Small
    • 1
  • Robert D. Woods
    • 2
  1. 1.National Institute of Environmental Health SciencesComparative Medicine BranchResearch Triangle ParkUSA
  2. 2.Agricultural Research Center, U.S. Department of AgricultureNational Animal Disease CenterAmesUSA

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