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Coronaviruses pp 483-492 | Cite as

The Neutralization Epitopes on the Spike Protein of Infectious Bronchitis Virus and their Antigenic Variation

  • H. G. M. Niesters
  • J. G. Kusters
  • J. A. Lenstra
  • W. J. M. Spaan
  • M. C. Horzined
  • B. A. M. van der Zeijst
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Avian infectious bronchitis virus (IBV) is the etiological agent of a highly contagious respiratory disease. It can cause high mortality, particulary in young chickens. Moreover, the kidneys and reproductive tract are often affected resulting in a drop of egg production in hens. In The Netherlands, infectious bronchitis (IB) used to be controlled by vaccination with the live attenuated virus strains H52 and H120, derived from field isolates (Bijlinga, 1956; Hoekstra and Rispens, 1960). Vaccination with these two strains resulted in protection against virtually all antigenic variants of the virus known at that time (Winterf ield and Fadley, 1975; Winterfield et al., 1976).

Keywords

Vaccine Strain Infectious Bronchitis Virus Neutralization Assay Neutralization Epitope Spike Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. G. M. Niesters
    • 1
  • J. G. Kusters
    • 1
  • J. A. Lenstra
    • 2
  • W. J. M. Spaan
    • 1
  • M. C. Horzined
    • 1
  • B. A. M. van der Zeijst
    • 2
  1. 1.Section BacteriologyState University UtrechtThe Netherlands
  2. 2.Institute of VirologyThe Netherlands

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