Resistance to Murine Hepatitis Virus Strain 3 (MHV-3) Infection in A/J Mice is not Affected by Cyclosporin A (CSA)
- 365 Downloads
Infection with mouse hepatitis virus strain 3 (MHV-3), causes a strain dependent spectrum of liver disease in inbred mice1. Mice of the A strain (A/J) are fully resistant to the virus and develop no evidence of liver disease. This resistance cannot be explained by restriction of viral replication, as high titers of infectious virus can be recovered from livers of these and resistant mice. Resistance to MHV-3 is dependent upon suitable numbers of both T cells and macrophages2 and immunosuppression with methylpredniso-lone, antilymphocyte globulin and cyclophosphamide results in conversion of resistance to susceptibility3.