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Coronaviruses pp 469-471 | Cite as

Resistance to Murine Hepatitis Virus Strain 3 (MHV-3) Infection in A/J Mice is not Affected by Cyclosporin A (CSA)

  • M. Abecassis
  • J. Falk
  • L. Makowka
  • V. Dindzans
  • R. Falk
  • G. Levy
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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Infection with mouse hepatitis virus strain 3 (MHV-3), causes a strain dependent spectrum of liver disease in inbred mice1. Mice of the A strain (A/J) are fully resistant to the virus and develop no evidence of liver disease. This resistance cannot be explained by restriction of viral replication, as high titers of infectious virus can be recovered from livers of these and resistant mice. Resistance to MHV-3 is dependent upon suitable numbers of both T cells and macrophages2 and immunosuppression with methylpredniso-lone, antilymphocyte globulin and cyclophosphamide results in conversion of resistance to susceptibility3.

Keywords

Liver Disease Infectious Virus Fulminant Hepatitis Sodium Succinate Plaque Form Unit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Levy, G. A., Leibowitz, J. L., Edgington, T. S. J. Exp. Med. 154: 1150: 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Levy, G. A., Leblond, E., Dupuy, J. M. J. Immunol. 118: 1219: 1977.Google Scholar
  3. 3.
    Sheets, P., Shah, K., Bark, F. B. Pro. Soc. Exp. Biol and Med. 159: 34: 1978.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Abecassis
    • 1
    • 2
  • J. Falk
    • 1
    • 2
  • L. Makowka
    • 1
    • 2
  • V. Dindzans
    • 1
    • 2
  • R. Falk
    • 1
    • 2
  • G. Levy
    • 1
    • 2
  1. 1.Departments of Medicine and SurgeryUniversity of TorontoTorontoCanada
  2. 2.Mount Sinai Hospital and Toronto General HospitalUniversity of TorontoTorontoCanada

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