Effect of Cyclosporin A on MHV3-Induced Chronic CNS Infection in Mice
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Intraperitoneal injection of MHV3 into adult C3H mice results either in early death due to hepatitis or in the development of a chronic disease with neurologic manifestations and virus persistence in surviving animals. The chronic neurologic disease which is described in another report in this volume, leads to meningitis, ependymitis, encephalitis and hydrocephalus followed by a chronic thrombotic vasculitis. In view of the potential therapeutic interest of Cyclosporin A (CsA), we decided to test its effects on the CNS lesions induced by MHV3.