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Coronaviruses pp 467-468 | Cite as

Effect of Cyclosporin A on MHV3-Induced Chronic CNS Infection in Mice

  • O. Boespflug
  • C. Godfraind
  • M. Tardieu
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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Intraperitoneal injection of MHV3 into adult C3H mice results either in early death due to hepatitis or in the development of a chronic disease with neurologic manifestations and virus persistence in surviving animals. The chronic neurologic disease which is described in another report in this volume, leads to meningitis, ependymitis, encephalitis and hydrocephalus followed by a chronic thrombotic vasculitis. In view of the potential therapeutic interest of Cyclosporin A (CsA), we decided to test its effects on the CNS lesions induced by MHV3.

Keywords

Infected Mouse Virus Persistence Untreated Control Animal Neuropathological Lesion Untreated Infected Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • O. Boespflug
    • 1
    • 2
  • C. Godfraind
    • 1
    • 2
  • M. Tardieu
    • 1
    • 2
  1. 1.INSERM U 56Hôpital de BicêtreBicêtreFrance
  2. 2.Laboratoire de neuropathologie du développementUCLBrusselsBelgique

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