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Coronaviruses pp 465-466 | Cite as

Prostaglandin E2 (PGE2) Alters the Pathogenesis of MHV-3 Infection in Susceptible Balb/cJ Mice

  • M. Abecassis
  • J. Falk
  • V. Dindzans
  • W. Lopatin
  • L. Makowka
  • G. Levy
  • R. Falk
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Murine hepatitis virus type 3 (MHV-3) produces a strain dependent pattern of disease in inbred strains of mice. Balb/cJ mice develop fulminant hepatitis following MHV-3 infection.1. Direct viral cytopathic effects do not account for the full spectrum of the disease and it appears that host immune factors are important in the pathogenesis of the disease. We have previously demonstrated that the induction of a specific macrophage protease (procoagulant activity (PCA)) correlates directly with susceptibility to disease and that it is responsible for disturbances in the microcirculation characterized by microthrombi, vasculitis, thrombosis and cellular necrosis.2. Little attention has been devoted to the effects of prostaglandins on viral infections. These studies were undertaken to examine the effect of 16, 16 dimethyl prostaglandin E2 on an experimental animal model of viral hepatitis.

Keywords

Hepatitis Virus Inbred Strain Cytopathic Effect Procoagulant Activity Mount Sinai Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Levy, G., Leibowitz, J. L., Edgington, T. S. Journal of Experimental Medicine 154: 1150: 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Macphee, P.J., Dindzans, V.J., Fung, L.S., Levy, G.A. Hepatology 5: 649: 1985.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Abecassis
    • 1
  • J. Falk
    • 1
  • V. Dindzans
    • 1
  • W. Lopatin
    • 1
  • L. Makowka
    • 1
  • G. Levy
    • 1
  • R. Falk
    • 1
  1. 1.Toronto General Hospital, Mount Sinai HospitalUniversity of TorontoTorontoCanada

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