Coronaviruses pp 449-450 | Cite as

Intranasal Challenge Immunity of Mice to Antigenically Homologous and Heterologous Strains of Mouse Hepatitis Virus

  • Stephen W. Barthold
  • Deborah S. Beck
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


The mutable nature and antigenic diversity among strains of coronaviruses, such as those of MHV, suggest an effective survival strategy for eluding immune clearance from host populations. Antigenic differences between MHV strains are largely expressed on peplomeric(E2) glycoproteins. Host neutralizing and type-specific antibodies are directed against E2 antigens.4 Challenge resistance can be induced by vaccination of mice with inactivated whole virus or peplomers, but not with virus membrane(E1) or nucleoprotein(N) subcomponents.5 Challenge resistance can also be induced with antibody to epitopes of E2.3, 6


Mouse Hepatitis Virus Virus Membrane Antigenic Difference Immune Clearance Antigenically Homologous 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Stephen W. Barthold
    • 1
  • Deborah S. Beck
    • 1
  1. 1.Section of Comparative MedicineYale University School of MedicineNew HavenUSA

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