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Coronaviruses pp 441-447 | Cite as

Coronavirus SD-Induced Immunoregulatory Disturbances in a Murine Model of Demyelination

  • Neil L. Rosenberg
  • Brian L. Kotzin
  • Maurice C. Kemp
  • Jack S. Burks
  • Thomas J. Santoro
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

We previously reported the isolation of coronaviruses while working with autopsy tissue from patients with multiple sclerosis1 and have been investigating the pathogenesis of these viruses in mice. Inoculation of three to four week old C57BL/6 mice with coronavirus SD induces a syndrome characterized by hindlimb anesthesia, paresis, or both between 4 and 9 days post-infection.2 We now report the finding of an unusual immunologic derangement in these mice.

Keywords

Multiple Sclerosis Experimental Autoimmune Encephalomyelitis Spleen Cell Infectious Virus Untreated Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    P. M. Mendelman, L. D. Jankovsky, R. S. Murray, P. Licari, B. DeVald, J. C. Gerdes, and J. S. Burks: Pathogenesis of coronavirus SD in mice. I. Prominent demyelination in the absence of infectious virus production. Arch. Neurol. 40: 493–498, 1983.PubMedCrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Neil L. Rosenberg
    • 1
    • 5
    • 6
    • 7
  • Brian L. Kotzin
    • 2
    • 3
    • 4
    • 5
  • Maurice C. Kemp
    • 1
    • 3
    • 6
  • Jack S. Burks
    • 1
    • 3
    • 6
  • Thomas J. Santoro
    • 2
    • 4
  1. 1.Dept. NeurologyUniv. Colorado School of MedicineUSA
  2. 2.Dept. MedicineUniv. Colorado School of MedicineUSA
  3. 3.Dept. Microbiology/ImmunologyUniv. Colorado School of MedicineUSA
  4. 4.Div. RheumatologyUniv. Colorado School of Medicine and Denver VA Medical CenterUSA
  5. 5.Research DivisionDenver VA Medical CenterUSA
  6. 6.Center for Neurological DiseasesRocky Mountain Multiple Sclerosis CenterUSA
  7. 7.Neurology Service (127)VA Medical CenterDenverUSA

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