Coronavirus SD-Induced Immunoregulatory Disturbances in a Murine Model of Demyelination
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We previously reported the isolation of coronaviruses while working with autopsy tissue from patients with multiple sclerosis1 and have been investigating the pathogenesis of these viruses in mice. Inoculation of three to four week old C57BL/6 mice with coronavirus SD induces a syndrome characterized by hindlimb anesthesia, paresis, or both between 4 and 9 days post-infection.2 We now report the finding of an unusual immunologic derangement in these mice.
KeywordsMultiple Sclerosis Experimental Autoimmune Encephalomyelitis Spleen Cell Infectious Virus Untreated Mouse