Coronaviruses pp 439-440 | Cite as

Neuropathogenicity of Mutant Strains of Mouse Hepatitis Virus, 1a and 2c, from DBT Cells Persistently Infected with JHM Strain

  • Naoaki Goto
  • Shinji Makino
  • Kosaku Fujiwara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


Two plaque mutants 1a and 2c of the mouse hepatitis virus JHM strain (MHV-JHM) from persistently infected DBT cells2 were examined for neuropathogenicity in mice. The mutant strains had peplomer proteins different from those of the original MHV-JHM3 and they were plaque purified.


Mutant Strain Infected Mouse Viral Antigen Mutant Virus Mouse Hepatitis Virus 
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    N. Goto, M. Takaoka, N. Hirano, K. Takahashi and K. Fujiwara, Neuro-pathogenicity of a mutant mouse hepatitis virus, JHM strain, derived from persistently infected DBT cells. Jpn. J. Vet. Sci. 46, 459–465. (1984).CrossRefGoogle Scholar
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    N. Hirano, N. Goto, S. Makino and K. Fujiwara, Persistent infection with mouse hepatitis virus JHM strain in DBT cell culture. pp. 301–308. In V. ter Meulen, S. Siddell and H. Wege (eds), Biochemistry and biology of coronaviruses, Pleunum Publishing Corporation, New York. (1981).Google Scholar
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    S. Makino, F. Taguchi, M. Hayami and K. Fujiwara, Characterization of small plaque mutant of mouse hepatitis virus, JHM strain. Microbiol. Immunol. 27, 445–454. (1983).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Naoaki Goto
    • 1
  • Shinji Makino
    • 2
  • Kosaku Fujiwara
    • 2
  1. 1.Department of Veterinary PathologyYamaguchi UniversityYamaguchiJapan
  2. 2.Department of Animal Pathology, Institute of Medical Sciencethe University of TokyoTokyoJapan

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