Neuropathogenicity of Mutant Strains of Mouse Hepatitis Virus, 1a and 2c, from DBT Cells Persistently Infected with JHM Strain
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Two plaque mutants 1a and 2c of the mouse hepatitis virus JHM strain (MHV-JHM) from persistently infected DBT cells2 were examined for neuropathogenicity in mice. The mutant strains had peplomer proteins different from those of the original MHV-JHM3 and they were plaque purified.
KeywordsMutant Strain Infected Mouse Viral Antigen Mutant Virus Mouse Hepatitis Virus
- 2.N. Hirano, N. Goto, S. Makino and K. Fujiwara, Persistent infection with mouse hepatitis virus JHM strain in DBT cell culture. pp. 301–308. In V. ter Meulen, S. Siddell and H. Wege (eds), Biochemistry and biology of coronaviruses, Pleunum Publishing Corporation, New York. (1981).Google Scholar