Intrathecal Humoral Immune Response in Corona Virus Induced Encephalo-Myelitis of Lewis and BN Rats
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Dependent on the variant of virus, the age and the strain of animals intracerebral infection of rats with the murine Corona virus JHM results in different diseases, ranging from acute lethal encephalitis (AE) to subacute demyelinating encephalomyelitis (SDE) (Wege et al., 1982). The delayed type of disease, SDE, can be observed most frequently after infection of weanling Lewis rats with JHM wild type virus (JHM-WT) or suckling rats with TS 43, a temperature sensitive mutant of JHM (JHM-TS43) (Wege et al., 1983). Clinically, SDE is characterized by hindleg paralysis, ataxic gait and severe impairment of growth. Histopathological changes include plaques of primary demyelination in the brain and spinal cord and perivascular cuffs of mononuclear cells. Viral antigens are demonstrable in phases of clinically apparent disease (Nagashima et al., 1978, 1979; Sorensen et al., 1980; Koga et al., 1984). Most likeley T lymphocytes as effector cells contribute to the pathogenesis of SDE, since Watanabe et al. (1983) demonstrated that lymphocytes from SDE animals, stimulated in vitro with basic myelin protein and transfered to syngeneic animals cause perivascular cuffing in the brain of the recipients comparable to the typical histopathological changes in animals suffering from experimental allergic encephalitis (EAE).
KeywordsCanine Distemper Virus Brown Norway Perivascular Cuff Intrathecal Synthesis Increase Blood Brain Barrier Permeability
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