Increased Hepatotropism of Mutants of MHV, Strain JHM, Selected with Monoclonal Antibodies
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The mouse hepatitis viruses (MHV) make up a group of closely related murine coronavi ruses which produce a wide spectrum of disease, depending upon the virus strain, the age and strain of the infected mouse, and the route of innoculation (Nelson, 1952; Gledhill and Neven, 1955). The determinants of the outcome of infection by MHV have been widely studied by many laboratories, with most groups concentrating their efforts on either the host response to the virus or on the viral genes responsible for virulence.
KeywordsInfected Mouse Parental Virus Escape Mutant Mouse Hepatitis Virus Murine Coronavirus
- Gledhill, A.W. and Neven, J.S.F. 1955. Latent virus as exemplified by mouse hepatitis virus. Vet. Rev. Annot. 1: 82–90.Google Scholar
- Rothfels, K.H., Axelrad, A.A., Siminovitch, L., McCulloch, E.A., and Parker, R.C. 1959. The origin of altered cell lines from mouse, monkey, and man as indicated by chromosome and transplantation studies. Can. Cancer Conf. 3: 189–214.Google Scholar