Coronavirus JHM Induced Demyelinating Disease: Specific Domains on the E2-Protein are Associated with Neurovirulence
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Infections of mice and rats with the coronavirus JHM are well established model systems to study mechanisms of virus in-duced demyelination9, 11, 13–15, 20–22, Massa et al., Dörries et al. this volume). Using virus strains originating from similar sources highly variable or even contradictory observations were made with regard to neurovirulence, type of disease and tropism for glial cells2, 3, 12. Despite of the highly advanced knowledge of virus structure at the molecular level the mechanisms of virus-host interactions important for pathogenesis are largely unknown. It had been shown previously, that intracerebral infection of Lewis rats can lead to encephalomyelitides associated with variable clinical symptoms and inflammatory demyelination. In most cases a rapidly progressing, fatal acute disease develops within 8–12 days p. i. (AE). Most interesting for studies of virus induced demyelination are animals, which show a slower onset of clinical signs (e. g. ataxic gait, paralysis) after incubation times of several weeks to months13, 14, 15. Such animals often survive, can suffer from clinical signs for months or sometimes develop a relapse21.
KeywordsAcute Hepatitis Cell Fusion Mouse Hepatitis Virus Murine Hepatitis Virus Murine Coronavirus
- 22.H. Wege, P.T. Massa, R. Dörries, R. Watanabe, and V. ter Meulen, Coronavirus infection of rats: a model for virus induced demyelinating disease associated with autoimmunity, in: Modern Trends in Virology (Bauer et al., eds., Springer Verlag (1986) (in press).Google Scholar