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Coronaviruses pp 307-320 | Cite as

Coronavirus JHM Induced Demyelinating Disease: Specific Domains on the E2-Protein are Associated with Neurovirulence

  • H. Wege
  • J. Winter
  • P. Massa
  • R. Dörries
  • V. ter Meulen
Chapter
  • 660 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Infections of mice and rats with the coronavirus JHM are well established model systems to study mechanisms of virus in-duced demyelination9, 11, 13–15, 20–22, Massa et al., Dörries et al. this volume). Using virus strains originating from similar sources highly variable or even contradictory observations were made with regard to neurovirulence, type of disease and tropism for glial cells2, 3, 12. Despite of the highly advanced knowledge of virus structure at the molecular level the mechanisms of virus-host interactions important for pathogenesis are largely unknown. It had been shown previously, that intracerebral infection of Lewis rats can lead to encephalomyelitides associated with variable clinical symptoms and inflammatory demyelination. In most cases a rapidly progressing, fatal acute disease develops within 8–12 days p. i. (AE). Most interesting for studies of virus induced demyelination are animals, which show a slower onset of clinical signs (e. g. ataxic gait, paralysis) after incubation times of several weeks to months13, 14, 15. Such animals often survive, can suffer from clinical signs for months or sometimes develop a relapse21.

Keywords

Acute Hepatitis Cell Fusion Mouse Hepatitis Virus Murine Hepatitis Virus Murine Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. Wege
    • 1
  • J. Winter
    • 1
  • P. Massa
    • 1
  • R. Dörries
    • 1
  • V. ter Meulen
    • 1
  1. 1.Institute of Virology and ImmunobiologyUniversity of WürzburgWürzburgGermany

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