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Sequence and Structure of the Coronavirus Peplomer Protein

  • R. J. de Groot
  • J. A. Lenstra
  • W. Luytjes
  • H. G. M. Niesters
  • M. C. Horzinek
  • B. A. M. van der Zeijst
  • W. J. M. Spaan
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

Coronaviruses display a characteristic fringe of large (17–20 nm), clubshaped peplomers, each consisting of a di- or trimer of the peplomer protein (Cavanagh et al. 1983). The peplomer protein, E2, plays an important role during the infection proces. It mediates the binding of virions to the host-cell receptors and is involved in membrane fusion. In addition, the E2 protein appears to be a major inducer of protective immunity to coronaviral infection (reviewed by Sturman and Holmes, 1983).

Keywords

Infectious Bronchitis Virus Coiled Coil Heptad Repeat Mouse Hepatitis Virus Infectious Bronchitis Virus Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. J. de Groot
    • 1
  • J. A. Lenstra
    • 2
  • W. Luytjes
    • 1
  • H. G. M. Niesters
    • 1
  • M. C. Horzinek
    • 1
  • B. A. M. van der Zeijst
    • 2
  • W. J. M. Spaan
    • 1
  1. 1.Institute of VirologyThe Netherlands
  2. 2.Section BacteriologyState University UtrechtThe Netherlands

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