Coronaviruses pp 287-295 | Cite as

Molecular Determinants of CNS Virulence of MHV-4

  • Michael J. Buchmeier
  • Robert G. Dalziel
  • Marck J. M. Koolen
  • Peter W. Lampert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)


Viral etiology is well established for at least two chronic progressive CNS diseases in man. Subacute sclerosing panencephalitis (SSPE) is a rare late complication of childhood measles characterized by a long time span between the initial attack and the onset of SSPE. This latent or silent phase may be a decade or longer, and the interaction between virus and host during this interval is poorly understood (1).


Progressive Multifocal Leukoencephalopathy Canine Distemper Virus Mouse Hepatitis Virus Subacute Sclerosing Panencephalitis Scripps Clinic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Michael J. Buchmeier
    • 1
  • Robert G. Dalziel
    • 1
  • Marck J. M. Koolen
    • 1
  • Peter W. Lampert
    • 1
    • 2
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA
  2. 2.University of CaliforniaSan DiegoUSA

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