Are Differences in Biological Properties of MHV Associated with Differences in Specific Regions of their Nucleocapsid mRNA?
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The purpose of this study is to compare specific regions of the nucleocapsid mRNA for murine coronavi ruses and to determine if any differences are associated with differences in pathogenicity. Murine hepatitis viruses (MHV) differ in the types of diseases they produce in rodents (see review1). In particular, MHV-JHM, causes demyelinating lesions in the central nervous system of many strains of rats while MHV-3 does not. MHV-A59 and MHV-S causes chronic demyelinating disease in mice. MHV-1 causes hepatitis in weanling VS mice.
KeywordsDemyelinating Disease Central Nervous System Infection Nucleocapsid Protein Synthetic Oligonucleotide Murine Hepatitis Virus
- 1.M. Piazza, Analogies Between Human and Animal Viral Hepatitis, in: “Experimental Viral Hepatitis,” Charles C. Thomas, Springfield (1969).Google Scholar