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Coronaviruses pp 157-158 | Cite as

Temporal Regulation of RNA Synthesis of Bovine Coronavirus

  • James G. Keck
  • Brenda G. Hogue
  • David A. Brian
  • Michael M. C. Lai
Chapter
  • 637 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 218)

Abstract

It has been shown with mouse hepatitis virus (MHV) and avian infectious bronchitis virus that all of the subgenomic mRNAs and genomic RNA are synthesized at the same rate throughout the viral replication cycle (Leibowitz et al., 1981; Stern and Kennedy, 1980). The viral genomic RNA gradually accumulates late in infection. However, no clear switching from transcription of subgenomic mRNAs to replication of genomic-sized RNA is seen. Thus, it is not known whether there is a temporal regulation of viral RNA synthesis in coronavirus-infected cells.

Keywords

Mouse Hepatitis Virus Viral Replication Cycle Avian Infectious Bronchitis Virus Bovine CORONAVIRUS Subgenomic mRNAs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Leibowitz, J.L., Wilhemsen, K.C. and Bond, C.W. The virus-specific intracellular RNA species of two murine coronaviruses: MHV-A59 and MHV-JHM. Virology 114: 29 (1981).CrossRefGoogle Scholar
  2. Stern, D.F. and Kennedy, S.I.T. Coronavirus multiplication strategy, I. Identification of characterization of virus-specified RNA. J. Virology 34: 665 (1980).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • James G. Keck
    • 1
  • Brenda G. Hogue
    • 2
  • David A. Brian
    • 2
  • Michael M. C. Lai
    • 1
  1. 1.Department of Microbiology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of MicrobiologyUniversity of TennesseeKnoxvilleUSA

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