The Use of Indirect Indicator Systems to Detect Mutagenic Activity in Human Subjects and Experimental Animals
Whereas exposure of human beings to potential mutagens is very likely increasing as a result of pollution from chemicals and chemical by-products used in or generated by agricultural and industrial operations as well as by drugs used for therapeutic purposes in medicine, evaluation of the genetic hazards associated with such exposure poses problems not amenable to simple solutions. Complete assessment of the mutagenic effect of a given chemical in human beings would require in the least not only considerable information on the genetic effects of the chemical and its possible interactions with other substances, but also information on the magnitude of health resources necessary to respond to such mutations. On the other hand, first steps can be taken in the identification of a potentially genetically hazardous compound by means of well-established detection procedures (and, in the future, by those under development and holding promise of success) devised and refined by many workers m a wide variety of organisms ranging from bacteria to subhuman mammals to man.
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