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Numerical Sex-Chromosome Anomalies in Mammals: Their Spontaneous Occurrence and Use in Mutagenesis Studies

  • Liane Brauch Russell
Part of the Chemical Mutagens book series

Abstract

Mutagenesis testing in intact mammals is increasingly becoming a prerequisite to any decision making that involves risk estimates. While the production of dominant lethals has been widely used as a convenient indicator of chromosomal damage, the interpretation of comparative experiments employing this method may be complex, especially when females are exposed and mutagenic effects must be distinguished from physiological ones acting via the mother. For this reason, other simple methods for measuring inherited chromosomal damage in the intact mammal have been developed.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Liane Brauch Russell
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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