Oxygen Uptake and Surfactant Replacement

  • B. Lachmann
  • S. Armbruster
  • W. Erdmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 222)


Increased capillary permeability, associated with damage to the alveolar epithelium, can lead to derangement of pulmonary surfactant through a variety of mechanisms. These include: washout of alveolar phospholipids into the interstitial tissue and blood stream; inactivation by plasma components; surfactant depletion by foaming or ventilation with large tidal volumes; disturbed synthesis, storage or release of surfactant secondary to direct injury to type II cells by hypoxemia, acidosis and hypoperfusion (for review see 1).


Adult Respiratory Distress Syndrome Pulmonary Surfactant Lung Lavage Natural Surfactant Capillary Leakage Syndrome 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. Lachmann
    • 1
  • S. Armbruster
    • 1
  • W. Erdmann
    • 1
  1. 1.Department of AnesthesiologyErasmus UniversityRotterdamThe Netherlands

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