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Oxygen Uptake and Surfactant Replacement

  • B. Lachmann
  • S. Armbruster
  • W. Erdmann
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 222)

Abstract

Increased capillary permeability, associated with damage to the alveolar epithelium, can lead to derangement of pulmonary surfactant through a variety of mechanisms. These include: washout of alveolar phospholipids into the interstitial tissue and blood stream; inactivation by plasma components; surfactant depletion by foaming or ventilation with large tidal volumes; disturbed synthesis, storage or release of surfactant secondary to direct injury to type II cells by hypoxemia, acidosis and hypoperfusion (for review see 1).

Keywords

Adult Respiratory Distress Syndrome Pulmonary Surfactant Lung Lavage Natural Surfactant Capillary Leakage Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. Lachmann
    • 1
  • S. Armbruster
    • 1
  • W. Erdmann
    • 1
  1. 1.Department of AnesthesiologyErasmus UniversityRotterdamThe Netherlands

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