The Effects of Mouse Hepatitis Virus Type 3 on the Microcirculation of the Liver in Inbred Strains of Mice
- 230 Downloads
Mouse Hepatitis Virus Type 3 (MHV-3) infection results in strain dependant liver disease. The acute effects of MHV-3 on the in vivo microcirculation of the liver in fully susceptible (Balb/cJ), fully resistant (A/J) mice and the chronic effects on C3H mice were studied. In Balb/cJ mice by 6 to 12 hours following infection, granular flow and sinusoidal microthrombi were present predominantly in periportal areas. By 24 to 48 hours, liver cell edema and small focal necrotic lesions were prominent. After 48 hours, thrombi and hepatocellular necrosis were widespread. The animals succumbed to the infection within 5 days.