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The Effects of Mouse Hepatitis Virus Type 3 on the Microcirculation of the Liver in Inbred Strains of Mice

  • G. A. Levy
  • P. J. MacPhee
  • L. S. Fung
  • M. M. Fisher
  • A. M. Rappaport
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)

Abstract

Mouse Hepatitis Virus Type 3 (MHV-3) infection results in strain dependant liver disease. The acute effects of MHV-3 on the in vivo microcirculation of the liver in fully susceptible (Balb/cJ), fully resistant (A/J) mice and the chronic effects on C3H mice were studied. In Balb/cJ mice by 6 to 12 hours following infection, granular flow and sinusoidal microthrombi were present predominantly in periportal areas. By 24 to 48 hours, liver cell edema and small focal necrotic lesions were prominent. After 48 hours, thrombi and hepatocellular necrosis were widespread. The animals succumbed to the infection within 5 days.

Keywords

Inbred Strain Granular Flow Endothelial Cell Injury Hepatocellular Necrosis Periportal Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. A. Levy
    • 1
  • P. J. MacPhee
    • 1
  • L. S. Fung
    • 1
  • M. M. Fisher
    • 1
  • A. M. Rappaport
    • 1
  1. 1.Liver Disease Unit, Department of Medicine, Sunnybrook Medical CenterUniversity of TorontoTorontoCanada

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