Antiviral Action of Interferon in the Bovine Species: Study InVitro and In Vivo
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Awaiting a multipotent antiviral vaccine preparation, perhaps a feasible goal for the future, there is still at the present time, we believe, enough room left for alternative ways to control viral diseases. Given the recent developments of bacterial production of interferon, the cost/benefits ratio of its possible use as antiviral has significantly increased. There is no more objective reason at this time to limit the investigations using interferon exclusively to the field of human health. Indeed, considerable economical interest could reside in an efficient way to control domestic animal viral diseases. We have undertaken the present study to evaluate interferon activity in the bovine species. As enough bovine interferon cannot be obtained for this purpose using our bovine cell system, we decided to use bacterially produced human interferon (Hu-IFNα2). It is readily available now and has been provided to us by Dr. C. WEISSMANN (Zürich University). This interferon was shown to cross the species barrier, using in vitro cell systems.
KeywordsBacterial Production Herpes Virus Common Cold Objective Reason Human Interferon
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