Advertisement

Antiviral Action of Interferon in the Bovine Species: Study InVitro and In Vivo

  • C. Vanden Broecke
  • P. P. Pastoret
  • A. Schwers
  • A. Goossens
  • B. Lansival
  • L. Bugyaki
  • L. Dagenais
  • J. Werenne
Chapter
  • 360 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)

Abstract

Awaiting a multipotent antiviral vaccine preparation, perhaps a feasible goal for the future, there is still at the present time, we believe, enough room left for alternative ways to control viral diseases. Given the recent developments of bacterial production of interferon, the cost/benefits ratio of its possible use as antiviral has significantly increased. There is no more objective reason at this time to limit the investigations using interferon exclusively to the field of human health. Indeed, considerable economical interest could reside in an efficient way to control domestic animal viral diseases. We have undertaken the present study to evaluate interferon activity in the bovine species. As enough bovine interferon cannot be obtained for this purpose using our bovine cell system, we decided to use bacterially produced human interferon (Hu-IFNα2). It is readily available now and has been provided to us by Dr. C. WEISSMANN (Zürich University). This interferon was shown to cross the species barrier, using in vitro cell systems.

Keywords

Bacterial Production Herpes Virus Common Cold Objective Reason Human Interferon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    L. Dagenais, P.P. Pastoret, C. Vanden Broecke, and J. Werenne Susceptibility of bovine rotavirus to interferon, Arch. of Virol., 70, 377–379 (1981)CrossRefGoogle Scholar
  2. 2.
    A. Goossens, A. Schwers, C. Vanden Broecke, L. Dagenais, M. Maenhoudt R. Duwijn, B. Van Camp, P.P. Pastoret, and J. Werenne. Sensibilité des virus de la Rhinotracheite infectieuse bovine (Bovine herpes virus I) et de la maladie d’Aujeszky (Suid herpes virus I) à l’interféron humain produit par des bactéries, Ann.Méd.Vét., 135–139 (1983)Google Scholar
  3. 3.
    G.M. Scott, R.J. Phillpotts, P.G. Higgins and D.J. Tyrell. Intranasal interferon against common colds. In “The biology of the interferon system” H. Schellekens Ed. Elsevier 1983 in pressGoogle Scholar
  4. 4.
    A. Goossens, A. Schwers, C. Vanden broecke, M. Maenhoudt, B. Bugyaki, P.P. Pastoret, J. Werenne. Antiviral efficiency of IFN in the bovine species: preliminary data on the activity in calves of bacterially produced human interferon (Hu-IFN±2)Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • C. Vanden Broecke
    • 1
  • P. P. Pastoret
    • 2
  • A. Schwers
    • 2
  • A. Goossens
    • 1
  • B. Lansival
    • 3
  • L. Bugyaki
    • 4
  • L. Dagenais
    • 2
  • J. Werenne
    • 1
  1. 1.Faculty of SciencesUniversity of BrusselsBelgium
  2. 2.Faculty of Veterinary MedicineUniversity of LiègeBelgium
  3. 3.Laboratory of VirologyMarloieBelgium
  4. 4.Institute of Hygiene and EpidemiologyBrusselsBelgium

Personalised recommendations