Pathogenicity of Mouse Hepatitis Virus, MHV-2cc, From a Persistently Infected DBT Cell Line

  • Naoaki Goto
  • Norio Hirano
  • Akio Sato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


Pathogenicity of a small plaque mutant of mouse hepatitis virus, MHV-2cc, from persistently infected DBT cell culture for nude mice (BALB/c) was studied. The mutant virus was purified by the same procedure as described previously1 by serial cultures of resistant DBT cells carrying MHV-2.


Nude Mouse Persistent Infection Chronic Active Hepatitis Mutant Virus Fulminant Hepatitis 
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  1. 1.
    N. Hirano, N. Goto, S. Makino, and K. Fujiwara. Persistent infection with mouse hepatitis virus, JHM strain in DBT cell culture. In Biochemistry and Biology of Coronavirus, Plenum Publishing, New York (1981).Google Scholar
  2. 2.
    T. Tamura, K. Ueda, N. Hirano, and K. Fujiwara. Response of nude mice to a mouse hepatitis virus isolated from a wasting nude mouse. Jpn. J. Exp. Med. 46, 19–30, (1967).Google Scholar
  3. 3.
    S. A. Stohlman, and L. P. Weiner. Stability of neurotropic mouse hepatitis virus (JHM strain) during chronic infection of neuroblastoma cells. Arch. Virol. 57, 53–61, (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Naoaki Goto
    • 1
  • Norio Hirano
    • 2
  • Akio Sato
    • 1
  1. 1.Department of Veterinary Pathology, Faculty of AgricultureYamaguchi UniversityJapan
  2. 2.Department of Microbiology, Faculty of AgricultureIwate UniversityYamaguchi 753Japan

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