Role of Circulating Antibodies and Thymus-Dependent Lymphocytes in Production of Effusive Type Feline Infectious Peritonitis After Oral Infection

  • Toshiharu Hayashi
  • Kunio Doi
  • Kosaku Fujiwara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


Seropositive or antibody-transferred kittens have been reported to have an overt disease after parenteral challenge with virulent feline infectious peritonitis (FIP) virus, suggesting that the effusive type FIP2,3 might result from an interaction between the virus and host response. On the other hand, feline leukemia virus infection was suggested to enhance the infection of FIP virus1. The present study deals with roles of circulating antibodies as well as thymus-dependent lymphocytes in pathogenesis after oral infection of FIP virus.


Present Study Deal Oral Infection Overt Disease Feline Infectious Peritonitis Parenteral Challenge 
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    S. M. Cotter, C. E. Gilmore, and C. Rollins. Multiple cases of feline leukemia and feline infectious peritonitis in a household, J.Am.Vet.Med.Assoc. 162, 1054–1058, (1973).PubMedGoogle Scholar
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    N. C. Pedersen, and J. F. Boyle. Immunologic phenomena in the effusive form of feline infectious peritonitis, Am.J.Vet.Res. 41, 868–876, (1980).Google Scholar
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    R. C. Weiss, and F. W. Scott. Pathogenesis of feline infectious peritonitis: Pathologic changes and immunofluorescence. Am.J.Vet.Res. 42, 2036–2048, (1980).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Toshiharu Hayashi
    • 1
  • Kunio Doi
    • 2
  • Kosaku Fujiwara
    • 1
  1. 1.Department of Veterinary Pathology, Faculty of AgricultureUniversity of TokyoBunkyo, Tokyo 113Japan
  2. 2.Department of Biomedical Science, Faculty of AgricultureUniversity of TokyoBunkyo, Tokyo 113Japan

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