The Immune Response to Mouse Hepatitis Virus: Genetic Variation in Antibody Response and Disease

  • Gary A. Levy
  • Robert Shaw
  • Julian L. Leibowitz
  • Edward Cole
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


Coronaviruses are a group of enveloped RNA viruses which can produce a broad spectrum of diseases in their natural hosts (1,2). These diseases include encephalitis, hepatitis, interstitial pneumonitis, nephritis and enteritis (3). The nature and the severity of the resultant disease varies with the age and the genetic background of the host, the route of infection and the size of the virus inoculum.


Nucleocapsid Protein Plaque Form Unit Mouse Hepatitis Virus Standard Plaque Assay High Titered Neutralize 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Robb JS, Bond CW: Coronaviridae I. Eds. H. Fraenkel-Conrat and RR Wagner Comprehensive Virology, Vol 14. Plenum Press, 1979, pp. 193–247.Google Scholar
  2. 2.
    Tyrell DAJ: Coronaviridae. Intervirology 10:321–336, 1978.CrossRefGoogle Scholar
  3. 3.
    Wege H, Sidell S and Ter Meulen V: The Biology and Pathogenesis of Coronaviruses. Ed. M Cooper Current Topics in Microbiology and Immunology. Vol 99, 1982, pp. 165–199.Google Scholar
  4. 4.
    Levy GA, Leibowitz JL and Edgington TS: Lymphocyte Instructed Monocyte Induction of the Coagulation Pathways Parallels the Induction of Hepatitis by the Murine Hepatitis Virus. IN: Progress in Liver Diseases eds: H Popper and F Schaffner, Grune and Stratton Inc. Vol 7, 1982, pp. 393–409.Google Scholar
  5. 5.
    Levy GA, Leibowitz JL and Edgington TS: Induction of Monocyte Procoagulant Activity by Murine Hepatitis Virus Type 3 Parallels Disease Susceptibility in Mice. J. Exp Med 154:1981:172.CrossRefGoogle Scholar
  6. 6.
    Levy-Leblond E and Dupuy JM: Neonatal Susceptibility to MHV Infections In Mice I. Transfer of Resistance. J. Immunol 118:1977:1219.PubMedGoogle Scholar
  7. 7.
    Bang F and Warwick A: Mouse macrophages as host cells for the mouse hepatitis virus and the genetic basis of their susceptibility. Proc Nat Acad Sci 46:1960:1065.PubMedCrossRefGoogle Scholar
  8. 8.
    Stohlman SA, Frelinger JA and Weiner LP: Resistance to fatal central nervous system disease by mouse hepatitis virus strain JHM II. Adherent Cell Mediated Protection. J. Immunol 124:1980:1733.PubMedGoogle Scholar
  9. 9.
    Mogensen SC: Genetics of macrophage controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice. Infect Immun 17:1977:268.PubMedGoogle Scholar
  10. 10.
    Mogensen SC: Role of Macrophages in Natural Resistance to Viral Infections. Microb Rev 43:1979:1.Google Scholar
  11. 11.
    Lawman MJR, Rouse BT, Courtney RJ, and Walker RD: Cell mediated immunity against herpes simplex:Induction and cytotoxic T lymphocytes. Infect Immun 27:1980:133.PubMedGoogle Scholar
  12. 12.
    Pfizenmaier K, Starzinski-Powitz A, Rollinghoff M, Falke D, and Wagner H: T cell mediated cytotoxicity against herpes simplex virus infected target cells. Nature 265:1977:630.PubMedCrossRefGoogle Scholar
  13. 13.
    Welsh RM: Mouse Natural Killer Cells. Induction Specificity and function. J. Immunol 121:1978:1631.PubMedGoogle Scholar
  14. 14.
    Lodmell DL and Notkins AL: Cellular Immunity to Herpes Simplex Virus Mediated By Interferons. J. Exp Med 140:1974:764.PubMedCrossRefGoogle Scholar
  15. 15.
    Gresser I, Tovey MG, Maury C, and Bandu MT: Role of Interferon in the Pathogenesis of Herpes Simplex Virus Disease in Mice. IARC Sci Pub. 24:1978:1049.Google Scholar
  16. 16.
    Virelizier JL: Pathogenicity and Persistence of mouse hepatitis virus in inbred strains of mice IN: Biochemistry and Biology of Coronaviruses. Advances in Exp Med and Biol Ed. V. Ter Meulen, S. Sidell and H. Wege Plenum Press Vol 142:1980:349.Google Scholar
  17. 17.
    Levy GL, Leibowitz JL and Edgington TS: Induction of Monocyte Procoagulant Activity by murine hepatitis virus type 3 parallels disease susceptibility in mice. J. Exp Med 154 No 4:1981:1254.CrossRefGoogle Scholar
  18. 18.
    Leibowitz JL, Fung LS and Levy GA: A sensitive radioimmunoassay for the detection of antibodies to MHV-3. J. Virol Methods In Press 1983.Google Scholar
  19. 19.
    Spiegelberg HL: Biological Activities of Immunoglobulins of different classes and subclasses. Adv. Immunol 19:1974:259.PubMedCrossRefGoogle Scholar
  20. 20.
    Grey HM, Hirst JW and Cohn M: J. Exp Med 133:1971:289.PubMedCrossRefGoogle Scholar
  21. 21.
    Karch H, Gmeiner J and Nixdorff K: Alterations of the Immunoglobulin G subclass responses in mice to 1ipopo1y saccharides: Effect of nonbacterial proteins and bacterial membrane phospholipids or outer membrane proteins of proteus mirabilis. Infect Immun 40:1983:157.PubMedGoogle Scholar
  22. 22.
    Rosenberg YJ and Asofsky R: T cell regulation of isotype expression. The requirement for a second Ig-specific helper T cell population for the induction of IgG responses. Eur J. Immun. 11:1981:705.CrossRefGoogle Scholar
  23. 23.
    Mongini PKA, Stein KE and Paul WE: T cell regulation of IgG subclass antibody production in response to T-independant antigens. J.Exp Med 153:1981:1.PubMedCrossRefGoogle Scholar
  24. 24.
    Herzenberg LA, Okumura K, Cantor H, Sato VL, Shen FW, Boyse EA and Herzenberg LA: T cell regulation of antibody responses: demonstration of allotype specific helper T cells and their specific removal by suppressor T cells. J. Exp Med 144:1976:330.PubMedCrossRefGoogle Scholar
  25. 25.
    Levy GA and Chisari FV: The immunopathogenesis of Hepatitis B Virus Induced Liver Disease. IN: Springer Seminars In Immunopathology. Eds Miescher PA and Muller-Eberhard HJ Springer-Verlag New York, N.Y. 3:1981:439.Google Scholar
  26. 26.
    Milich DR and Chisari FV: Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg) I Restriction of the murine humoral immune response to the a and d determinants of HBsAG. J. Immunol 129:1982:320.PubMedGoogle Scholar
  27. 27.
    Delacroix DL, Elkon KB, Geubel AP, Hodgson HF, Dive C and Vaerman JP: Changes in size, subclass and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A. J. Clin Invest. 71:1983:358.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Gary A. Levy
    • 1
  • Robert Shaw
    • 1
  • Julian L. Leibowitz
    • 2
  • Edward Cole
    • 1
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada
  2. 2.Department of PathologyUniversity of California at San DiegoLa JollaUSA

Personalised recommendations