Proteolytic Cleavage of Peplomeric Glycoprotein E2 of MHV Yields Two 90K Subunits and Activates Cell Fusion

  • Lawrence S. Sturman
  • Kathryn V. Holmes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 173)


During the past decade our laboratories have been studying the structure and functions of coronavirus glycoproteins. Several years ago, based on our studies with mouse hepatitis virus (MHV)-A59, we proposed a schematic model of the molecular organization of the coronavirus particle (Sturman et al., 1980). This model appears to be valid for most other coronaviruses as well (Garwes, 1980; Siddell et al., 1982). Our current representation of the structure of MHV-A59 is shown in Fig. 1 (Sturman and Holmes, 1983).


Cell Fusion Infectious Bronchitis Virus Mouse Hepatitis Virus 180K Form Avian Infectious Bronchitis Virus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Lawrence S. Sturman
    • 1
  • Kathryn V. Holmes
    • 2
  1. 1.Center for Laboratories and ResearchNew York State Department of HealthAlbanyUSA
  2. 2.Department of Pathology, The Uniformed ServicesUniversity of the Health SciencesBethesdaUSA

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