Proteolytic Cleavage of Peplomeric Glycoprotein E2 of MHV Yields Two 90K Subunits and Activates Cell Fusion
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During the past decade our laboratories have been studying the structure and functions of coronavirus glycoproteins. Several years ago, based on our studies with mouse hepatitis virus (MHV)-A59, we proposed a schematic model of the molecular organization of the coronavirus particle (Sturman et al., 1980). This model appears to be valid for most other coronaviruses as well (Garwes, 1980; Siddell et al., 1982). Our current representation of the structure of MHV-A59 is shown in Fig. 1 (Sturman and Holmes, 1983).
KeywordsCell Fusion Infectious Bronchitis Virus Mouse Hepatitis Virus 180K Form Avian Infectious Bronchitis Virus
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